Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration
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Date
2025-06
Journal Title
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Publisher
Wolters Kluwer – Medknow
Abstract
Purpose: We aim to evaluate the changes in the size of drusens and drusenoid pigment epithelial detachments (PED) in patients with age?related macular degeneration. Design: This study was designed as an observational retrospective cohort study. Methods: We evaluated eyes with drusenoid PED tracked using spectral?domain and enhanced depth imaging optical coherence tomography. The cases were classified according to the follow?up visits and divided into two groups as eyes with collapsed PED and persisting PED. The best?corrected visual acuity (BCVA), size of drusens and PED, central macular thickness (CMT), and subfoveal choroidal thickness (SCT) were recorded. Results: We included 11 patients’ 22 eyes with drusenoid PED. In the final comparison, the mean CMT, SCT, and BCVA were significantly lower in Group 1 compared to Group 2 (P = 0.05; P = 0.05; P = 0.002, respectively). The mean CMT, SCT, and BCVA were significantly decreased from baseline to the last visit in Group 1 (P = 0.013; P < 0.001; P = 0.001, respectively). No significant changes were observed regarding the mean CMT, SCT, and BCVA in Group 2 during the follow?up visits. (P = 0.317, P = 0.682, P = 0.056). Conclusion: Spontaneous collapse of drusenoid PED is associated with poor visual outcome.
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Keywords
Central macular thickness, drusen, non?neovascular age?related macular degeneration, pigment epithelial detachment, subfoveal choroidal thickness
Citation
Karabulut Sinem, Kaderli Sema Tamer, Karalezli Aylin. Long-term outcomes of drusenoid retinal pigment epithelium detachment in eyes with age-related macular degeneration. Indian Journal of Ophthalmology. 2025 Jun; 73(6): 843-846