CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei

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dc.contributor.authorAdhya, AKen_US
dc.contributor.authorSingh, Aen_US
dc.contributor.authorMuduly, DKen_US
dc.contributor.authorSahoo, B.en_US
dc.date.accessioned2025-06-19T05:55:11Z
dc.date.available2025-06-19T05:55:11Z
dc.date.issued2025-03
dc.description.abstractMucinous carcinomas arising within an ovarian dermoid tumor are rare. Most of the cases reported in the literature show morphological features resembling an appendiceal mucinous neoplasm. They exhibit CK7?/CK20+ immunophenotype similar to carcinomas of the lower gastrointestinal tract. In this report, we have described a case of a well?differentiated mucinous carcinoma arising within a mature cystic teratoma. The mucinous carcinoma showed a spectrum of morphological patterns, including cystadenoma?like areas, proliferative/ borderline areas, villous adenoma?like areas, and areas of invasive carcinoma. In addition, our case showed some unusual findings, namely, diffuse CK7 positivity, associated pseudomyxoma peritonei, and metastasis to lungs. These features were not demonstrated in any of the previously reported cases. Our case shows that the teratomatous mucinous neoplasm of the ovary may show CK7+/CK20+/ CDX2 + immunoprofile making it immunohistochemically indistinguishable from a primary ovarian mucinous neoplasm or a metastatic mucinous carcinoma of the lower gastrointestinal tract.en_US
dc.identifier.affiliationsDepartments of Pathology and Lab Medicineen_US
dc.identifier.affiliationsSurgical Oncologyen_US
dc.identifier.affiliationsSurgical Oncologyen_US
dc.identifier.affiliationsRadiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.citationAdhya AK, Singh A, Muduly DK, Sahoo B.. CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 183-189en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249949
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume68en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_1255_21en_US
dc.subjectCDX2en_US
dc.subjectCK7en_US
dc.subjectCK20en_US
dc.subjectmature teratomaen_US
dc.subjectteratomatous mucinous carcinomaen_US
dc.titleCK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritoneien_US
dc.typeJournal Articleen_US
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