Microwave ablation after VATS in patients with multiple pulmonary nodules
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Date
2024-12
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer – Medknow
Abstract
Background: The management of residual nodules after video‑assisted thoracoscopic surgery (VATS) for multiple pulmonary nodules (MPNs) is challenging. Microwave ablation (MWA), which is highly repeatable and minimally invasive, has garnered widespread attention in the treatment of MPNs. Methods: Ninety‑one patients with MPNs who underwent VATS for resection of high‑risk nodules followed by MWA for residual nodules were examined. Clinical efficacy and complications were assessed. The primary end points were MWA success rate and complete ablation rate. Secondary end points were local progression‑free survival (LPFS), overall survival (OS), and complications. Results: MWA was successfully completed in all patients. Mean tumor diameter, ablation time, and ablation output power were 0.81 cm, 3.4 minutes, and 39 W, respectively. LPFS was 100% at 3, 6, 12, and 24 months, respectively. OS was 100% at 12 and 24 months, respectively. No intraoperative or postoperative deaths occurred. Complications with MWA were infrequent. Pneumothorax was most common, occurring in 31 patients (34.07%); among these, seven (7.69%) required closed thoracic drainage. Pleural effusion occurred in six patients (6.59%), hydropneumothorax in five (5.49%), and pneumonia in three (3.30%). The pain level after MWA was moderate‑to‑severe in 29 patients (31.87%). Conclusion: MWA is safe and feasible for treating residual nodules in patients with MPNs who have undergone VATS. The incidence of complications was low, and most complications were mild.
Description
Keywords
Microwave ablation (MWA), multiple pulmonary nodules (MPNs), simultaneous multiple primary lung cancer (SMPLC), video‑assisted thoracoscopic surgery (VATS)
Citation
Cui Xiangyu, Zhao Jinglan, Lu Ruizhen, Sui Yingzhong, Shao Changqing, Zhang Zhixue, Chen Jun. Microwave ablation after VATS in patients with multiple pulmonary nodules. Journal of Cancer Research and Therapeutics. 2024 Dec; 20(7): 2029-2034