Predictive Value of Frailty Index in Comparison to Traditional Markers of Sepsis in Predicting Mortality among Elderly Admitted in Tertiary Care Hospital

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dc.contributor.authorMurlidharan, Aen_US
dc.contributor.authorDhar, Men_US
dc.contributor.authorPathania, Men_US
dc.contributor.authorAgarwal, Mayanken_US
dc.contributor.authorSethi, Prativa Pen_US
dc.contributor.authorSaxena, Vartikaen_US
dc.contributor.authorBhat, Nowneet Ken_US
dc.date.accessioned2023-06-17T08:20:25Z
dc.date.available2023-06-17T08:20:25Z
dc.date.issued2022-09
dc.description.abstractIntroduction: The frailty index’s potential as a prognostic marker of sepsis is so far been untapped. Here we studied the predictive value of frailty index in the elderly with sepsis. Methods: This prospective cohort study was conducted in a tertiary level hospital in North India. The duration of the study was 18 months starting from January 2020 to July 2021. The frailty index was calculated along with traditional markers of sepsis such as sequential organ failure assessment (SOFA), quick sequential organ failure assessment (qSOFA), and systemic inflammatory response syndrome (SIRS) within 24 hours of admission in elderly patients suspected to have sepsis. The area under the receiver operating characteristic (AUROC) of frailty index, SOFA, qSOFA, and SIRS was compared for in-hospital and 3-month mortality. Results: There was no significant difference between the performance of the frailty index and SOFA (DeLong’s test p = 0.242) in predicting in-hospital mortality, but there was a statistical difference between the AUROC of SOFA score (AUC = 0.548) and frailty in predicting 3-month mortality (DeLong’s test p ?0.001). Conclusion: The frailty index had greater sensitivity and negative predictive value among the other scores in predicting in-hospital mortality, whereas SOFA had higher specificity in predicting in-hospital mortality. The frailty index was superior to SOFA and the other prognostic markers of sepsis in predicting 3-month mortality.en_US
dc.identifier.affiliationsJunior Residenten_US
dc.identifier.affiliationsAdditional Professoren_US
dc.identifier.affiliationsAssociate Professor, Department of Internal Medicineen_US
dc.identifier.affiliationsProfessor, Department of Community and Family Medicineen_US
dc.identifier.affiliationsProfessor, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, Indiaen_US
dc.identifier.citationMurlidharan A, Dhar M, Pathania M, Agarwal Mayank, Sethi Prativa P, Saxena Vartika, Bhat Nowneet K. Predictive Value of Frailty Index in Comparison to Traditional Markers of Sepsis in Predicting Mortality among Elderly Admitted in Tertiary Care Hospital. Journal of the Association of Physicians of India. 2022 Sep; 70(9): 32-36en_US
dc.identifier.issn0004 – 5772
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216272
dc.languageenen_US
dc.publisherAssociation of Physicians of Indiaen_US
dc.relation.issuenumber9en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.5005/japi-11001-0094en_US
dc.titlePredictive Value of Frailty Index in Comparison to Traditional Markers of Sepsis in Predicting Mortality among Elderly Admitted in Tertiary Care Hospitalen_US
dc.typeJournal Articleen_US
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