Study of pulmonary hypertension as a complication of sickle cell disease

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dc.contributor.authorBakhtar, Vijayen_US
dc.contributor.authorBakhtar, Niyatien_US
dc.contributor.authorBakhtar, Nikhilen_US
dc.contributor.authorPandey, Kiriten_US
dc.date.accessioned2020-04-09T07:43:29Z
dc.date.available2020-04-09T07:43:29Z
dc.date.issued2020-02
dc.description.abstractBackground: Sickle cell anaemia is the most common inherited hematological abnormality across human race, particularly prevalent in pockets of central India and pulmonary hypertension (PH) supposedly worsens prognosis. Data from central India is lacking though. Present study aims to study incidence of pulmonary hypertension as a complication in patients of sickle cell disease.Methods: Patients aged more than 12 years diagnosed to have sickle cell anaemia on hemoglobin electrophoresis during the study period (total- 94; 54 SS and 40 AS) were enrolled as cases. Sixty four age/sex matched healthy close relatives of the cases with 慉A� Hb electrophoresis pattern doubled up as controls. Participants were thoroughly assessed with complete history, examination, haematological and biochemical tests, X-ray chest, ECG, pulmonary function tests and 2D-echocardiography and Doppler studies and data analysed.Results: Pulmonary hypertension was observed in a total of five SS cases (5/54, 9.26%). No participant from the AS group or the control group developed pulmonary hypertension. It was more common in females (3/23, 13%) than males (2/26, 7.7%). The mean age of the SS cases with PH (32�15 years) was found to be significantly higher than that of the SS cases without PH (24.2�21 years) (p<0.01).Conclusions: The incidence of PH in sickle cell disease was relatively lower as compared to western countries and was found to affect females and older individuals more. Larger community-based studies are recommended for corroboration.en_US
dc.identifier.affiliationsDepartment of Medicine, Dr. Panjabrao Deshmukh Memorial Medical College, Amravati, Maharashtra, Indiaen_US
dc.identifier.affiliationsIntern, District Hospital, Amravati, Maharashtra, Indiaen_US
dc.identifier.affiliationsConsultant Physician, Bakhtar Hospital, Amravati, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, Armed Forces Medical College, Pune, Maharashtra, Indiaen_US
dc.identifier.citationBakhtar Vijay, Bakhtar Niyati, Bakhtar Nikhil, Pandey Kirit. Study of pulmonary hypertension as a complication of sickle cell disease. International Journal of Advances in Medicine. 2020 Feb; 7(2): 297-302en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194586
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20200084en_US
dc.subjectComplicationen_US
dc.subjectElectrophoresisen_US
dc.subjectPulmonary hypertensionen_US
dc.subjectPrognosisen_US
dc.subjectSickle cell anaemiaen_US
dc.subjectSickle cell diseaseen_US
dc.titleStudy of pulmonary hypertension as a complication of sickle cell diseaseen_US
dc.typeJournal Articleen_US
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