Tumor volume as a prognostic factor on the median survival in locally advanced oral cancer treated with definitive chemoradiotherapy
dc.contributor.author | Janmunee, Narumon | en_US |
dc.contributor.author | Peerawong, Thanarpan | en_US |
dc.contributor.author | Rordlamool, Paytai | en_US |
dc.contributor.author | Bridthikitti, Jidapa | en_US |
dc.contributor.author | Tangthongkum, Manupol | en_US |
dc.contributor.author | Kongkamol, Chanon | en_US |
dc.contributor.author | Hirunpa, Siriporn | en_US |
dc.date.accessioned | 2023-08-09T06:04:27Z | |
dc.date.available | 2023-08-09T06:04:27Z | |
dc.date.issued | 2023-03 | |
dc.description.abstract | Background: Surgery has been the mainstay treatment for oral cancer. Patients who do not receive surgery are generally treated with concurrent chemoradiotherapy (CCRT). Many factors play a role in patients� survival; tumor volume might be one of those factors. This study aims to determine the effect of the pre-treatment tumor volume on the survival of oral cancer. Methods: Retrospective study of patients with histological confirmed squamous cell carcinoma, stage III朓V oral cancer, who received definitive CCRT. Tumor volume from pre-treatment computed tomography (CT) scans were reviewed and analyzed. The optimal cut-off tumor volume was evaluated by receiver operating characteristic (ROC) curve analysis. Results: Among 67 patients, half of the primary tumor sites were oral tongue. The median total tumor volume (TTV) was 73.25 cm3, while the median survival was 12.5 months (95% confidence interval: 10.9-20.3). The optimal cut-off TTV ?52.9 cm3 (P < 0.0001). The median survival of the patients, who had tumor volume <52.9 cm3 were 34.4 months, and for tumor volume ?52.9 cm3 were 8.6 months (P < 0.0001). Multivariate analysis showed that TTV ?52.9 cm3, and intensity-modulated radiotherapy (IMRT) or volumetric-modulated arc therapy (VMAT) technique had significantly influenced the overall survival. Conclusion: TTV had an influence on the overall survival of locally advanced oral cancer. In addition, TTV may be considered as a factor in selecting the appropriate treatment option for these patients. | en_US |
dc.identifier.affiliations | Department of Radiology | en_US |
dc.identifier.affiliations | Department of Otolaryngology Head and Neck Surgery, and | en_US |
dc.identifier.affiliations | Research Unit of Holistic Health and Safety Management in the Community, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand | en_US |
dc.identifier.citation | Janmunee Narumon, Peerawong Thanarpan, Rordlamool Paytai, Bridthikitti Jidapa, Tangthongkum Manupol, Kongkamol Chanon, Hirunpa Siriporn. Tumor volume as a prognostic factor on the median survival in locally advanced oral cancer treated with definitive chemoradiotherapy. Indian Journal of Cancer . 2023 Mar; 60(1): 72-79 | en_US |
dc.identifier.issn | 0019-509X | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/221757 | |
dc.language | en | en_US |
dc.publisher | Wolters Kluwer - Medknow | en_US |
dc.relation.issuenumber | 1 | en_US |
dc.relation.volume | 60 | en_US |
dc.source.uri | https://doi.org/10.4103/ijc.IJC_86_20 | en_US |
dc.subject | Chemoradiotherapy | en_US |
dc.subject | mouth neoplasms | en_US |
dc.subject | survival | en_US |
dc.subject | tumor burden | en_US |
dc.title | Tumor volume as a prognostic factor on the median survival in locally advanced oral cancer treated with definitive chemoradiotherapy | en_US |
dc.type | Journal Article | en_US |
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