Tumor volume as a prognostic factor on the median survival in locally advanced oral cancer treated with definitive chemoradiotherapy

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dc.contributor.authorJanmunee, Narumonen_US
dc.contributor.authorPeerawong, Thanarpanen_US
dc.contributor.authorRordlamool, Paytaien_US
dc.contributor.authorBridthikitti, Jidapaen_US
dc.contributor.authorTangthongkum, Manupolen_US
dc.contributor.authorKongkamol, Chanonen_US
dc.contributor.authorHirunpa, Siripornen_US
dc.date.accessioned2023-08-09T06:04:27Z
dc.date.available2023-08-09T06:04:27Z
dc.date.issued2023-03
dc.description.abstractBackground: Surgery has been the mainstay treatment for oral cancer. Patients who do not receive surgery are generally treated with concurrent chemoradiotherapy (CCRT). Many factors play a role in patients� survival; tumor volume might be one of those factors. This study aims to determine the effect of the pre-treatment tumor volume on the survival of oral cancer. Methods: Retrospective study of patients with histological confirmed squamous cell carcinoma, stage III朓V oral cancer, who received definitive CCRT. Tumor volume from pre-treatment computed tomography (CT) scans were reviewed and analyzed. The optimal cut-off tumor volume was evaluated by receiver operating characteristic (ROC) curve analysis. Results: Among 67 patients, half of the primary tumor sites were oral tongue. The median total tumor volume (TTV) was 73.25 cm3, while the median survival was 12.5 months (95% confidence interval: 10.9-20.3). The optimal cut-off TTV ?52.9 cm3 (P < 0.0001). The median survival of the patients, who had tumor volume <52.9 cm3 were 34.4 months, and for tumor volume ?52.9 cm3 were 8.6 months (P < 0.0001). Multivariate analysis showed that TTV ?52.9 cm3, and intensity-modulated radiotherapy (IMRT) or volumetric-modulated arc therapy (VMAT) technique had significantly influenced the overall survival. Conclusion: TTV had an influence on the overall survival of locally advanced oral cancer. In addition, TTV may be considered as a factor in selecting the appropriate treatment option for these patients.en_US
dc.identifier.affiliationsDepartment of Radiologyen_US
dc.identifier.affiliationsDepartment of Otolaryngology Head and Neck Surgery, anden_US
dc.identifier.affiliationsResearch Unit of Holistic Health and Safety Management in the Community, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailanden_US
dc.identifier.citationJanmunee Narumon, Peerawong Thanarpan, Rordlamool Paytai, Bridthikitti Jidapa, Tangthongkum Manupol, Kongkamol Chanon, Hirunpa Siriporn. Tumor volume as a prognostic factor on the median survival in locally advanced oral cancer treated with definitive chemoradiotherapy. Indian Journal of Cancer . 2023 Mar; 60(1): 72-79en_US
dc.identifier.issn0019-509X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221757
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume60en_US
dc.source.urihttps://doi.org/10.4103/ijc.IJC_86_20en_US
dc.subjectChemoradiotherapyen_US
dc.subjectmouth neoplasmsen_US
dc.subjectsurvivalen_US
dc.subjecttumor burdenen_US
dc.titleTumor volume as a prognostic factor on the median survival in locally advanced oral cancer treated with definitive chemoradiotherapyen_US
dc.typeJournal Articleen_US
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