Chloroquine resistant Plasmodium falciparum: effect of rabbit serum and incubation time on the in vitro (microtechnique) prediction of in vivo resistance.

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dc.contributor.authorSmrkovski, L Len_US
dc.contributor.authorAlcantara, Aen_US
dc.contributor.authorBuck, R Len_US
dc.contributor.authorSy, N Een_US
dc.contributor.authorRodriguez, C Sen_US
dc.contributor.authorMacalagay, P Sen_US
dc.contributor.authorUylangco, C Ben_US
dc.date.accessioned2009-05-27T16:38:59Z
dc.date.available2009-05-27T16:38:59Z
dc.date.issued1983-06-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractA study of chloroquine resistance of 54 isolates of Plasmodium falciparum is reported. Sixty-four percent of the isolates tested produced schizonts in vitro (micro-technique), whereas the remaining 36 percent did not. The accuracy of the in vitro test to predict in vivo resistance was increased when the primary parasite isolates were cultured in the presence of rabbit serum and when the cultures were allowed to incubate for more than 48 hours. Thirteen isolates of P. falciparum that showed in vitro resistance were confirmed in vivo resistant. Eleven of these cases were identified as R-I and two as R-II. Only one case of in vivo resistance (R-II) was observed among the 19 isolates that failed to produce schizonts in vitro.en_US
dc.identifier.citationSmrkovski LL, Alcantara A, Buck RL, Sy NE, Rodriguez CS, Macalagay PS, Uylangco CB. Chloroquine resistant Plasmodium falciparum: effect of rabbit serum and incubation time on the in vitro (microtechnique) prediction of in vivo resistance. The Southeast Asian Journal of Tropical Medicine and Public Health. 1983 Jun; 14(2): 228-34en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/35696
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlooden_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshCulture Mediaen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria --drug therapyen_US
dc.subject.meshPlasmodium falciparum --drug effectsen_US
dc.subject.meshRabbitsen_US
dc.titleChloroquine resistant Plasmodium falciparum: effect of rabbit serum and incubation time on the in vitro (microtechnique) prediction of in vivo resistance.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
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