Quantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors.

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dc.contributor.authorSrikanth, Ken_US
dc.contributor.authorKumar, C Aen_US
dc.contributor.authorGoswami, Den_US
dc.contributor.authorDe, A Uen_US
dc.contributor.authorJha, Ten_US
dc.date.accessioned2001-02-21en_US
dc.date.accessioned2009-05-27T09:35:54Z
dc.date.available2001-02-21en_US
dc.date.available2009-05-27T09:35:54Z
dc.date.issued2001-02-21en_US
dc.description.abstractAs a part of a composite programme of rational drug design (RDD), we had synthesized some substituted benzenesulphonyl glutamines and evaluated their inhibitory activities against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. Quantitative structure activity relationship (QSAR) studies of these inhibitory activities using Fujita-Ban model as well as Modified Hansch-Fujita model gave excellent correlations (correlation coefficient r = 0.89 and 0.82 respectively). These results could be useful in designing 'lead' compound with potent inhibitory activity on DNA and RNA synthesis and tumour development.en_US
dc.description.affiliationNatural Science Laboratory, Division of Medicinal Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.en_US
dc.identifier.citationSrikanth K, Kumar CA, Goswami D, De AU, Jha T. Quantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors. Indian Journal of Biochemistry & Biophysics. 2001 Feb-Apr; 38(1-2): 120-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27987
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBenzenesulfonates --chemistryen_US
dc.subject.meshDNA --chemistryen_US
dc.subject.meshGlutamine --chemistryen_US
dc.subject.meshMiceen_US
dc.subject.meshModels, Chemicalen_US
dc.subject.meshModels, Theoreticalen_US
dc.subject.meshRNA --chemistryen_US
dc.subject.meshStructure-Activity Relationshipen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleQuantitative structure activity relationship (QSAR) studies of some substituted benzenesulphonyl glutamines as tumour suppressors.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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