Correlation of severity & clinical outcomes of COVID-19 with virus variants: A prospective, multicentre hospital network study

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dc.contributor.authorWadhwa, Komalen_US
dc.contributor.authorMalik, Shilpaen_US
dc.contributor.authorBalaji, Srinigilaen_US
dc.contributor.authorThiruvengadam, Ramachandranen_US
dc.contributor.authorBashyam, Murali Dharanen_US
dc.contributor.authorBhattacharya, Prasanta Kumaren_US
dc.contributor.authorBehera, Bijayinien_US
dc.contributor.authorBhardwaj, Pankajen_US
dc.contributor.authorBiswas, Nidhan K.en_US
dc.contributor.authorDas, Asimen_US
dc.contributor.authorDey, Anindyaen_US
dc.contributor.authorDhotre, Dhirajen_US
dc.contributor.authorDias, Maryen_US
dc.contributor.authorDubey, Pankajen_US
dc.contributor.authorDutta, Shreelekhaen_US
dc.contributor.authorGadepalli, Ravisekharen_US
dc.contributor.authorGosain, Muditaen_US
dc.contributor.authorGoud, Kalal Iravatyen_US
dc.contributor.authorGupta, Neeraj Kumaren_US
dc.contributor.authorGupta, Niteshen_US
dc.contributor.authorJana, Pradiptaen_US
dc.contributor.authorJena, Deepaken_US
dc.contributor.authorJohn, Elizabethen_US
dc.contributor.authorKarunanidhi, Arunkumaren_US
dc.contributor.authorKhan, S. Muhammad Salimen_US
dc.contributor.authorKhattar, Sahilen_US
dc.contributor.authorPaul, Abhilash Prabhakar Kundavaramen_US
dc.contributor.authorKumar, Shaktien_US
dc.contributor.authorMaitra, Arindamen_US
dc.contributor.authorModi, Nikhilen_US
dc.contributor.authorMoorthy, Maheshen_US
dc.contributor.authorNagaraj, Savithaen_US
dc.contributor.authorPalakodeti, Dasaradhien_US
dc.contributor.authorPandey, Anil Kumaren_US
dc.contributor.authorPandey, Aparnaen_US
dc.contributor.authorRaghav, Sunil Kumaren_US
dc.contributor.authorRamasubban, Sureshen_US
dc.contributor.authorRaghavan, Sreevatsanen_US
dc.contributor.authorHarikrishnan, S.en_US
dc.contributor.authorKrishnamoorthy, S.en_US
dc.contributor.authorSelvamurugan, Selvarajen_US
dc.contributor.authorSardana, Ramanen_US
dc.contributor.authorShouche, Yogeshen_US
dc.contributor.authorSingh, Akankshaen_US
dc.contributor.authorSingh, Arvind Kumaren_US
dc.contributor.authorRamasubramaniyan, V.en_US
dc.contributor.authorYadav, Monikaen_US
dc.contributor.authorZahoor, Danishen_US
dc.contributor.authorNarreddy, Suneethaen_US
dc.contributor.authorBhatnagar, Shinjinien_US
dc.contributor.authorWadhwa, Nityaen_US
dc.contributor.authorDas, Bhabatoshen_US
dc.contributor.authorGarg, Pramod Kumaren_US
dc.date.accessioned2025-05-09T09:44:53Z
dc.date.available2025-05-09T09:44:53Z
dc.date.issued2024-01
dc.description.abstractBackground & objectives: The clinical course of COVID-19 and its prognosis are influenced by both viral and host factors. The objectives of this study were to develop a nationwide platform to investigate the molecular epidemiology of SARS-CoV-2 (Severe acute respiratory syndrome Corona virus 2) and correlate the severity and clinical outcomes of COVID-19 with virus variants. Methods: A nationwide, longitudinal, prospective cohort study was conducted from September 2021 to December 2022 at 14 hospitals across the country that were linked to a viral sequencing laboratory under the Indian SARS-CoV-2 Genomics Consortium. All participants (18 yr and above) who attended the hospital with a suspicion of SARS-CoV-2 infection and tested positive by the reverse transcription–PCR method were included. The participant population consisted of both hospitalized as well as outpatients. Their clinical course and outcomes were studied prospectively. Nasopharyngeal samples collected were subjected to whole genome sequencing to detect SARS-CoV-2 variants. Results: Of the 4972 participants enrolled, 3397 provided samples for viral sequencing and 2723 samples were successfully sequenced. From this, the evolution of virus variants of concern including Omicron subvariants which emerged over time was observed and the same reported here. The mean age of the study participants was 41 yr and overall 49.3 per cent were female. The common symptoms were fever and cough and 32.5 per cent had comorbidities. Infection with the Delta variant evidently increased the risk of severe COVID-19 (adjusted odds ratio: 2.53, 95% confidence interval: 1.52, 4.2), while Omicron was milder independent of vaccination status. The independent risk factors for mortality were age >65 yr, presence of comorbidities and no vaccination. Interpretation & conclusions: The authors believe that this is a first-of-its-kind study in the country that provides real-time data of virus evolution from a pan-India network of hospitals closely linked to the genome sequencing laboratories. The severity of COVID-19 could be correlated with virus variants with Omicron being the milder variant.en_US
dc.identifier.affiliationsClinical Development Services Agency, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsClinical Development Services Agency, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsClinical Development Services Agency, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsCenter for Maternal and Child Health, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsLaboratory of Molecular Oncology, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of General Medicine, North Eastern Indira Gandhi Regional Institute, Shillong, Meghalaya, Indiaen_US
dc.identifier.affiliationsDepartment of Microbilogy, All India Institute of Medical Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsNational Institute of Biomedical Genomics, Kalyani, Indiaen_US
dc.identifier.affiliationsESIC Medical College & Hospital, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Apollo Hospitals, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsNational Centre for Cell Science, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsNational Centre for Cell Science, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Critical Care, Apollo Hospitals, Ahmedabad, Gujarat, Indiaen_US
dc.identifier.affiliationsNational Institute of Biomedical Genomics, Kalyani, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.affiliationsCenter for Maternal and Child Health, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsMolecular Biology and Cytogenetics, Apollo Hospitals, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Critical Care and Sleep Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Critical Care and Sleep Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, Indiaen_US
dc.identifier.affiliationsInfection and Immunology, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment ofImmunogenomics & Systems Biology Lab, Institute of Life Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsInstitute for Stem Cell Science & Regenerative Medicine, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsCentre for DNA Fingerprinting & Diagnostics, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, Government Medical College, Srinagar, Jammu & Kashmir, Indiaen_US
dc.identifier.affiliationsCenter for Data Management, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsEmergency Department, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsInfection and Immunology, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsNational Institute of Biomedical Genomics, Kalyani, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Critical Care and Sleep Medicine, Apollo Hospitals, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, St. Johns Medical College & Hospital, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsInstitute for Stem Cell Science & Regenerative Medicine, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsMedical Superindent, ESIC Medical College & Hospital, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, ESIC Medical College & Hospital, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment ofImmunogenomics & Systems Biology Lab, Institute of Life Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Critical care, Apollo Hospitals, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsCenter for Maternal and Child Health, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonology, Apollo Hospitals, Madurai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Internal Medicine, Apollo Hospitals, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Research, Apollo Hospitals, Madurai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Apollo Hospitals, New Delhi, Indiaen_US
dc.identifier.affiliationsNational Centre for Microbiol Resource, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsClinical Development Services Agency, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Infectious Diseases and Tropical Medicine, Apollo Hospitals, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsClinical Development Services Agency, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Government Medical College, Srinagar, Jammu & Kashmir, Indiaen_US
dc.identifier.affiliationsDepartments of Infectious Medicine, Apollo Hospitals, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsCenter for Maternal and Child Health, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsCenter for Maternal and Child Health, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsInfection and Immunology, Faridabad, Haryana, Indiaen_US
dc.identifier.affiliationsTranslational Health Science & Technology Institute, Faridabad, Haryana, Indiaen_US
dc.identifier.citationWadhwa Komal, Malik Shilpa, Balaji Srinigila, Thiruvengadam Ramachandran, Bashyam Murali Dharan, Bhattacharya Prasanta Kumar, Behera Bijayini, Bhardwaj Pankaj, Biswas Nidhan K., Das Asim, Dey Anindya, Dhotre Dhiraj, Dias Mary, Dubey Pankaj, Dutta Shreelekha, Gadepalli Ravisekhar, Gosain Mudita, Goud Kalal Iravaty, Gupta Neeraj Kumar, Gupta Nitesh, Jana Pradipta, Jena Deepak, John Elizabeth, Karunanidhi Arunkumar, Khan S. Muhammad Salim, Khattar Sahil, Paul Abhilash Prabhakar Kundavaram, Kumar Shakti, Maitra Arindam, Modi Nikhil, Moorthy Mahesh, Nagaraj Savitha, Palakodeti Dasaradhi, Pandey Anil Kumar, Pandey Aparna, Raghav Sunil Kumar, Ramasubban Suresh, Raghavan Sreevatsan, Harikrishnan S., Krishnamoorthy S., Selvamurugan Selvaraj, Sardana Raman, Shouche Yogesh, Singh Akanksha, Singh Arvind Kumar, Ramasubramaniyan V., Yadav Monika, Zahoor Danish, Narreddy Suneetha, Bhatnagar Shinjini, Wadhwa Nitya, Das Bhabatosh, Garg Pramod Kumar. Correlation of severity & clinical outcomes of COVID-19 with virus variants: A prospective, multicentre hospital network study. Indian Journal of Medical Research. 2024 Jan; 159(1): 91-101en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/244896
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume159en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.ijmr_1041_23en_US
dc.subjectCOVID-19en_US
dc.subjectDeltaen_US
dc.subjectOmicronen_US
dc.subjectSARS-CoV-2en_US
dc.subjectseverityen_US
dc.subjectvariants of concernen_US
dc.titleCorrelation of severity & clinical outcomes of COVID-19 with virus variants: A prospective, multicentre hospital network studyen_US
dc.typeJournal Articleen_US
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