CD14 C-159T polymorphism and its association with chronic lung diseases: A pilot study on isocyanate exposed population of Central India.

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dc.contributor.authorBose, Protiti
dc.contributor.authorBathri, Rashmi
dc.contributor.authorDe, Sajal
dc.contributor.authorMaudar, K K
dc.date.accessioned2013-11-20T08:41:51Z
dc.date.available2013-11-20T08:41:51Z
dc.date.issued2013-04
dc.description.abstractCONTEXT: CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to influence the cytokine profile and subsequent immunoglobulin E production in response to antigen/allergen contact in allergic phenotypes. AIMS: The present study was to investigate genetic polymorphism in CD14 gene - 159C/T, which may be one of the risk factor for increased prevalence of Chronic Lung Diseases in the Central India. SETTINGS AND DESIGN: Survivors of Methyl isocyanates toxicity in Bhopal still suffering from various respiratory ailments were examined. MATERIALS AND METHODS: Polymerase chain reaction-restriction fragment length polymorphism was performed to determine the polymorphism of C-159T. RESULTS: The genotype and allelic frequencies were in Hardy-Weinberg’s equilibrium. Prevalence of CC, CT, and TT were 5.5%, 22.2% and 9.25% respectively in asthmatics; 16.6%, 20.3% and 5.5% respectively in chronic obstructive pulmonary disease (COPD) patients and 5.5%, 14.8% and 1.85 respectively among interstitial lung disorder (ILD) patients; whereas the control cohort with no methyl isocyanate exposure displayed (CC, CT, and TT) cytosine, thymine as 2%, 1.6% and 2% respectively. Increased risk of Asthma among those carrying TT genotype and T allele (odds ratio [OR] =2.61 and 2.02 respectively). CONCLUSION: COPD risk significantly found among those with CC genotype and C allele (OR = 2.81 and 1.50 respectively), whereas ILD risk found significantly among CT genotype and C allele (OR = 1.75 and 1.40 respectively). Therefore, single nucleotide polymorphism (SNP) C-159T polymorphism in CD14 gene might be a risk factor for development of CLD in this population.en_US
dc.identifier.citationBose Protiti, Bathri Rashmi, De Sajal, Maudar K K. CD14 C-159T polymorphism and its association with chronic lung diseases: A pilot study on isocyanate exposed population of Central India. Indian Journal of Human Genetics. 2013 Apr; 19(2): 188-195.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/149428
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758726/?report=classicen_US
dc.subjectAsthmaen_US
dc.subjectBhopalen_US
dc.subjectCD14en_US
dc.subjectchronic obstructive methyl isocyanateen_US
dc.subjectpulmonary diseaseen_US
dc.subject.meshAged
dc.subject.meshAntigens, CD14 --genetics
dc.subject.meshAsthma --epidemiology
dc.subject.meshBhopal Accidental Release
dc.subject.meshChronic Disease
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIsocyanates --adverse effects
dc.subject.meshLung Diseases --chemically induced
dc.subject.meshLung Diseases --epidemiology
dc.subject.meshLung Diseases --etiology
dc.subject.meshLung Diseases --genetics
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Genetic
dc.subject.meshPopulation Groups --epidemiology
dc.subject.meshPopulation Groups --genetics
dc.titleCD14 C-159T polymorphism and its association with chronic lung diseases: A pilot study on isocyanate exposed population of Central India.en_US
dc.typeArticleen_US
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