Hepatocarcinogenesis in viral Hepatitis B infection: the role of HBx and p53.

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dc.contributor.authorDewantoro, Oktoen_US
dc.contributor.authorGani, Rino Aen_US
dc.contributor.authorAkbar, Nurulen_US
dc.date.accessioned2006-07-06en_US
dc.date.accessioned2009-05-28T04:34:15Z
dc.date.available2006-07-06en_US
dc.date.available2009-05-28T04:34:15Z
dc.date.issued2006-07-06en_US
dc.description20 references.en_US
dc.description.abstractInfection of Hepatitis B Virus (HBV) is a risk factor of chronic active hepatitis (CAH), hepatic cirrhosis and hepatocellular carcinoma (HCC). Infection of HBV may develop to HCC without antecedent hepatic cirrhosis. Pathogenesis of HBV causing malignant changes has not been fully understood. HBx, a protein of HBV, is an activator of transcription process involved in hepatocarcinogenesis. Most of human cancer associated with mutation of p53, a Tumor Suppressor Genes, a protein serves as cellular protection for growth and cell division, which is one of predisposition factor of hepatocarcinoma. Some studies indicate the correlation between mutation / inactivation of p53 and HBV protein x (HBx) in hepatocarcinogenesis. In that process, HBx will suppress p53 function, which will lead to ineffective liver cell division and resulting in HCC.en_US
dc.description.affiliationDepartement of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta.en_US
dc.identifier.citationDewantoro O, Gani RA, Akbar N. Hepatocarcinogenesis in viral Hepatitis B infection: the role of HBx and p53. Acta Medica Indonesiana. 2006 Jul-Sep; 38(3): 154-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/47089
dc.language.isoengen_US
dc.subject.meshCarcinoma, Hepatocellular --etiologyen_US
dc.subject.meshHepatitis B --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms --etiologyen_US
dc.subject.meshTumor Suppressor Protein p53 --metabolismen_US
dc.subject.meshViral Regulatory and Accessory Proteins --metabolismen_US
dc.titleHepatocarcinogenesis in viral Hepatitis B infection: the role of HBx and p53.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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