Anti-HBs Titers Following Pentavalent Immunization (DTwP- HBV-Hib) in Term Normal Weight vs Low Birthweight Infants

Simple item page
dc.contributor.authorVerma, Chandrikaen_US
dc.contributor.authorMMA, Faridien_US
dc.contributor.authorNarang, Manishen_US
dc.contributor.authorKaur, Iqbal Ren_US
dc.date.accessioned2020-04-23T07:42:35Z
dc.date.available2020-04-23T07:42:35Z
dc.date.issued2018-05
dc.description.abstractObjective: To compare anti-HBs titers between term low birthweight (1800-2499 g) infants and normal birthweight infants, 6weeks after last dose of primary immunization with pentavalentvaccine, and to study adverse events following immunization(AEFI) with pentavalent vaccine.Design: Cohort study.Setting: Tertiary-care hospital predominantly catering to urbanpoor population of East Delhi.Participants: 265 low birthweight (1800-2499 g) and 265 normalbirthweight (2500-4000 g) infants. Monovalent Hepatitis B vaccinewas administered within 24 hours of birth followed by three primarydoses of pentavalent vaccine at 6, 10 and 14 weeks. Anti-HBstiters were estimated after 6 weeks of third dose of pentavalentvaccine. Adverse events following immunization (AEFI) monthwere observed for a month after each dose of pentavalent vaccine.Main outcome measures: Anti HBs antibody titers after 6 weeksof primary immunization, and AEFI.Result: 443 (83.5%) infants (225 low birthweight and 218 normalbirthweight infants) completed the follow-up. Seroprotectionagainst hepatitis B virus was achieved in both groups afterpentavalent vaccine administration. Anti HBs GMTs in lowbirthweight infants (194.8 mIU/mL) and normal birthweight infants(204.2 mIU/mL) were comparable (P = 0.17). No serious adverseevents were observed in either group.Conclusion: Three primary doses of pentavalent vaccineadministered along with zero dose of Hepatitis B vaccine at birthprovide good seroprotection. The vaccine appears to be safe inboth low birth weight and normal birthweight infants born at term.en_US
dc.identifier.affiliationsDepartments of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, Indiaen_US
dc.identifier.affiliationsMicrobiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.en_US
dc.identifier.citationVerma Chandrika, MMA Faridi, Narang Manish, Kaur Iqbal R. Anti-HBs Titers Following Pentavalent Immunization (DTwP- HBV-Hib) in Term Normal Weight vs Low Birthweight Infants. Indian Pediatrics. 2018 May; 55(5): 395-399en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199083
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber5en_US
dc.relation.volume55en_US
dc.source.urihttps://www.indianpediatrics.net/may2018/395.pdfen_US
dc.subjectCombination vaccinesen_US
dc.subjectHepatitis B vaccineen_US
dc.subjectImmunogenicityen_US
dc.subjectLow birthweight infantsen_US
dc.titleAnti-HBs Titers Following Pentavalent Immunization (DTwP- HBV-Hib) in Term Normal Weight vs Low Birthweight Infantsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ip2018v55n5p395.pdf
Size:
33.28 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Pediatrics