Detection of JC virus infection in progressive multifocal leukoencephalopathy: the first documented case in Thailand.

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dc.contributor.authorDujneungkunakorn, Taweekiaten_US
dc.contributor.authorSungkanuparph, Somnueken_US
dc.contributor.authorVibhagool, Asdaen_US
dc.contributor.authorPairoj, Wantaniten_US
dc.contributor.authorChantratita, Wasunen_US
dc.contributor.authorSrichunrusami, Chutatipen_US
dc.contributor.authorLaothamatas, Jirapornen_US
dc.contributor.authorPulkes, Teeratornen_US
dc.date.accessioned2009-05-27T21:11:45Z
dc.date.available2009-05-27T21:11:45Z
dc.date.issued2002-10-28en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractProgressive Multifocal Leukoencephalopathy (PML) is a demyelinating brain disease caused by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clinical and neuroradiological findings. The authors report a 36-year-old woman who presented with prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the need for a brain biopsy in such cases.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.en_US
dc.identifier.citationDujneungkunakorn T, Sungkanuparph S, Vibhagool A, Pairoj W, Chantratita W, Srichunrusami C, Laothamatas J, Pulkes T. Detection of JC virus infection in progressive multifocal leukoencephalopathy: the first documented case in Thailand. Journal of the Medical Association of Thailand. 2002 Oct; 85(10): 1139-44en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44363
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAcquired Immunodeficiency Syndrome --complicationsen_US
dc.subject.meshAdulten_US
dc.subject.meshAntiretroviral Therapy, Highly Activeen_US
dc.subject.meshAntiviral Agents --therapeutic useen_US
dc.subject.meshBiopsyen_US
dc.subject.meshCerebrospinal Fluid --virologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshJC Virus --isolation & purificationen_US
dc.subject.meshLeukoencephalopathy, Progressive Multifocal --complicationsen_US
dc.subject.meshNeurosurgical Proceduresen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleDetection of JC virus infection in progressive multifocal leukoencephalopathy: the first documented case in Thailand.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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