Evaluation of the Biological Response to Acetylsalicylic Acid by Platelet Occlusion Time in Pregnant Women in Brazzaville

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dc.contributor.authorGokaba, LOen_US
dc.contributor.authorSamba, JEen_US
dc.contributor.authorAtipo-Tsiba, OGen_US
dc.contributor.authorBuambo, Gen_US
dc.contributor.authorNgolet, Len_US
dc.contributor.authorIwandza, Ren_US
dc.contributor.authorAmboulou, PIen_US
dc.contributor.authorMboumba, JNen_US
dc.contributor.authorBango, Cen_US
dc.contributor.authorItoua, Cen_US
dc.contributor.authorDokekias, AE.en_US
dc.date.accessioned2025-05-09T06:23:06Z
dc.date.available2025-05-09T06:23:06Z
dc.date.issued2024-03
dc.description.abstractLow-dose acetylsalicylic acid (ASA) has been recommended for pregnant women since 2011 by the OMS to prevent thrombotic phenomena. Despite the variability of its clinical efficacy (resistance phenomena), its non-standardized biological monitoring can be performed using platelet occlusion time (POT). The aim of this study was to assess the response to ASA using POT. A multicenter, cross-sectional, analytical study was conducted in the obstetrics and gynaecology departments of six Brazzaville hospitals over a period of 09 months and included pregnant women on ASA 100 mg daily for at least 7 days. POT was measured using the INNOVANCE® PFA®-200 system. The variables studied were clinical (age, medical and obstetrical history) and biological (blood count, POT). Non-response to ASA was defined by a POT of 150 seconds or less. Data analysis was performed using STATA 12 software. Logistic regression was used to assess the determinants associated with non-response. The incidence of obstetric complications according to ASA resistance was evaluated by the Kaplan-Meier method and the Log-Rank test. The significance threshold was p<0.005. The study involved 39 pregnant women, mean age 33.9 ± 5.4 years, treated with ASA for hypertensive disorders of pregnancy n=19 (48.7%), chronic arterial hypertension n=7 (18%), diabetes n=3(7.7%) fetal death n=3(7.7%), unexplained miscarriage n=3(7.7%), advanced age n=2 (5.1%) and twin pregnancy n=2(5.1%). The median body index was 25.5 kg/m2 [23.7;29.4] with 35.9% women of normal weight, 48.7% overweight and 15.4% obese. Non-response to ASA was found in 12 pregnant women (30.7%). No statistically significant differences were observed between non-responders and responders with regard to epidemiological, clinical and haematological determinants (p>0.05). Non-response was more observed in women with complications 23.08% versus 7.7% (p=0,008). Non-response to ASA, present in a third of hypertensive pregnant women, is associated with the occurrence of obstetrical complications in Brazzaville.en_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congo and Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congoen_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congoen_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congo and Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congoen_US
dc.identifier.affiliationsFaculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congoen_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congo and Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congoen_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congoen_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congoen_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congoen_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congoen_US
dc.identifier.affiliationsFaculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congoen_US
dc.identifier.affiliationsNational Reference Center for Sickle Cell Disease ''Antoinette SASSOU N'GUESSO'' Brazzaville, Congo and Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congoen_US
dc.identifier.citationGokaba LO, Samba JE, Atipo-Tsiba OG, Buambo G, Ngolet L, Iwandza R, Amboulou PI, Mboumba JN, Bango C, Itoua C, Dokekias AE. . Evaluation of the Biological Response to Acetylsalicylic Acid by Platelet Occlusion Time in Pregnant Women in Brazzaville . International Blood Research & Reviews. 2024 Mar; 15(1): 18-25en_US
dc.identifier.issn2321-7219
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242678
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber1en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.9734/ibrr/2024/v15i1331en_US
dc.subjectpregnancyen_US
dc.subjectacetylsalicylic aciden_US
dc.subjectPFA-200en_US
dc.subjectbiological responseen_US
dc.titleEvaluation of the Biological Response to Acetylsalicylic Acid by Platelet Occlusion Time in Pregnant Women in Brazzavilleen_US
dc.typeJournal Articleen_US
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