Level of undercarboxylated osteocalcin in reproductive Thai females.

dc.contributor.authorBunyaratavej, Narongen_US
dc.contributor.authorSoontrapa, Suppasinen_US
dc.contributor.authorRojanasthin, Sattayaen_US
dc.contributor.authorKitimanon, Nipaten_US
dc.contributor.authorLektrakul, Songkiaten_US
dc.date.accessioned2009-05-27T18:05:00Z
dc.date.available2009-05-27T18:05:00Z
dc.date.issued2005-10-28en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOsteocalcin is a vitamin K dependent protein requiring vitamin K as a cofactor for the enzyme gamma glutamyl carboxylase which converts the glutamate residues at 17, 21, 24 position of the molecule into gamma carboxyglutamate or Gla residues.The carboxylation makes immature osteocalcin or undercarboxylated osteocalcin (ucOC) into mature osteocalcin which enhances calcium binding in bone. The level of undercarboxylated osteocalcin is recognized as a marker of vitamin K2 bone.The level of undercarboxylated osteocalcin is recognized as a marker of vitamin K2 in blood necessary for this process. Mature osteocalcin has a higher affinity for hydroxyapatite than undercarboxylated osteocalcin. Foreign studies have shown that ucOC level is increased in elderly women and postmenopausal women in comparison with young, healthy, reproductive women and level of ucOC is also the marker to predict the risk of hip fracture. The standard value of undercarboxylated osteocalcin in Thai women is not available. The aim of the present study was to find the level of ucOC in reproductive Thai females. 357 healthy female volunteers who had regular menstruation, 20-50 years of age, average age 38.5 years old. The volunteers had no intake of any kind of medicine affecting bone metabolism before blood examination. The mean value of undercarboxylated osteocalcin is 2.69 ng/ml, median is 2.10_ng/ml standard deviation = 2.02,_standard error = 0.107 with 95% confident interval = 2.485 to 2.906 ng/ml. In the authors previous pilot study in elderly and postmenopausal women, the authors found that the mean of ucOC in Thai elderly and postmenopausal women was higher than that of reproductive women.en_US
dc.description.affiliationDepartment of Orthopaedic Surgery, Faculty of Medicine, Mahidol University, Bangkok 10700, Thailand. todrnarong@yahoo.comen_US
dc.identifier.citationBunyaratavej N, Soontrapa S, Rojanasthin S, Kitimanon N, Lektrakul S. Level of undercarboxylated osteocalcin in reproductive Thai females. Journal of the Medical Association of Thailand. 2005 Oct; 88 Suppl 5(): S37-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38419
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshBiological Markersen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteocalcin --blooden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshThailanden_US
dc.subject.meshVitamin K --blooden_US
dc.subject.meshVitamin K Deficiency --enzymologyen_US
dc.titleLevel of undercarboxylated osteocalcin in reproductive Thai females.en_US
dc.typeJournal Articleen_US
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