The world of synbiotics: a review of literature and clinical evidence in diarrhoea from the lens of a paediatrician

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dc.contributor.authorJog, Pramoden_US
dc.date.accessioned2020-09-24T07:42:51Z
dc.date.available2020-09-24T07:42:51Z
dc.date.issued2019-01
dc.description.abstractThe use of synbiotics in the management of acute diarrhoea in children is becoming a common practice in India. However, since this is an upcoming modality of treatment, it is essential to review the scientific rationale and evidence on clinical efficacy and safety in the context of paediatric diarrhoea. In addition, most synbiotics contain a combination of multiple probiotics along with a prebiotic. Thus arises, a parallel need to understand whether a combination of probiotics performs better than single probiotics, hence justifying the rationale for such combinations. A review of available evidence suggests that synbiotics are indeed safe and superior in efficacy to single probiotics (like Bacillus clausii, Lactobacillus rhamnosus GG etc) and that there is a good body of evidence to support the efficacy and tolerability of synbiotics in the management of paediatric acute gastroenteritis. There is also evidence to suggest that combination probiotics have superior benefits compared to single probiotics, thus justifying their use as part of synbiotics. The overall benefits of synbiotics reported in various clinical trials on paediatric diarrhoea include, a rapid normalization of the gastrointestinal flora, a reduction in the duration of diarrhoea, quicker improvement in stool consistency, lesser administration of additional medications like antibiotics, antiemetics and antipyretics, higher physician reported treatment satisfaction scores and enhanced overall efficacy against gastrointestinal pathogens, including diarrhoea of rota virus origin. Hence, synbiotics put up a strong case to look beyond probiotics and single probiotic formulations in paediatric diarrhoea.en_US
dc.identifier.affiliationsDepartment of Pediatrics, D. Y. Patil Medical college, Pune, Maharashtra, Indiaen_US
dc.identifier.citationJog Pramod. The world of synbiotics: a review of literature and clinical evidence in diarrhoea from the lens of a paediatrician. International Journal of Contemporary Pediatrics. 2019 Jan; 6(1): 233-242en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203884
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20185219en_US
dc.subjectCombination probioticsen_US
dc.subjectDiarrhoeaen_US
dc.subjectMulti-strain probioticsen_US
dc.subjectPrebioticsen_US
dc.subjectProbioticsen_US
dc.subjectSynbioticsen_US
dc.titleThe world of synbiotics: a review of literature and clinical evidence in diarrhoea from the lens of a paediatricianen_US
dc.typeJournal Articleen_US
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