Spatio-temporal tumour model for analysis and mechanism of action of intracellular drug accumulation.

Simple item page
dc.contributor.authorMishra, Somnaen_US
dc.contributor.authorKatiyar, V Ken_US
dc.date.accessioned2008-09-14en_US
dc.date.accessioned2009-06-01T14:38:15Z
dc.date.available2008-09-14en_US
dc.date.available2009-06-01T14:38:15Z
dc.date.issued2008-09-14en_US
dc.description.abstractWe have developed a one-dimensional tumour simulator to describe the biodistribution of chemotherapeutic drugs to a tumoral lesion and the tumour cell's response to therapy. A three-compartment model is used for drug dynamics within the tumour. The first compartment represents the extracellular space in which cells move, the second corresponds to the intracellular fluid space (including cell membrane) which is in direct equilibrium with the extracellular space, and the third is a non-exchangeable compartment that represents sequestered drug which is trapped in the nucleus to damage the cellular DNA,directly triggering cell death. Analytical and numerical techniques (Finite Element Method) are used to describe the tumour's response to therapy and the effect of parameter variation on the drug concentration profiles in the three compartments.en_US
dc.description.affiliationDepartment of Information Technology, Institute of Management Studies, Dehradun, India. mishra_somna@yahoo.comen_US
dc.identifier.citationMishra S, Katiyar VK. Spatio-temporal tumour model for analysis and mechanism of action of intracellular drug accumulation. Journal of Biosciences. 2008 Sep; 33(3): 381-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110968
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAntineoplastic Agents --administration & dosageen_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshFinite Element Analysisen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshNeoplasms --drug therapyen_US
dc.subject.meshTime Factorsen_US
dc.titleSpatio-temporal tumour model for analysis and mechanism of action of intracellular drug accumulation.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of Biosciences