Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.

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dc.contributor.authorUllal, G Ren_US
dc.contributor.authorSatishchandra, Pen_US
dc.contributor.authorShankar, S Ken_US
dc.date.accessioned1996-10-01en_US
dc.date.accessioned2009-06-01T05:02:46Z
dc.date.available1996-10-01en_US
dc.date.available2009-06-01T05:02:46Z
dc.date.issued1996-10-01en_US
dc.description.abstractHyperthermic seizures were elicited in groups of freely ambulant rats with jets of hot water of 55 degrees C on the head for about 10 mins. Bipolar depth EEG from the hippocampus and the behavioural seizures following the stimulation were recorded. The rectal temperature (threshold) for seizure initiation was 41.5 degrees C. The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s. After 3 stimulations (once a day), Phenobarbitone (Pb) 0.02 mg/g daily, Diphenylhydantoin (DPH) 0.001 mg/g, 0.005 mg/g and 0.04 mg/g. daily and Nifedipine (Nif) 0.005 mg/g twice daily were administered intraperitoneally in different rats. During the 10-days injection trials, Pb completely suppressed seizures whereas DPH and Nif did not have any effect. One of the rats with DPH showed increased epileptic activity. After a 10 day 'washout' period' Pb and DPH were interchanged and again the rats were tested for seizures on 10 days. On changing over to Pb from DPH there was complete suppression of seizures and electrical seizure discharges. Whereas those rats which earlier had no seizure activity with Pb started showing the same on changing over to DPH.en_US
dc.description.affiliationDepartment of Physiology, M. S. Ramaiah Medical College, Bangalore.en_US
dc.identifier.citationUllal GR, Satishchandra P, Shankar SK. Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. Indian Journal of Physiology and Pharmacology. 1996 Oct; 40(4): 303-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106309
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticonvulsants --pharmacologyen_US
dc.subject.meshBody Temperatureen_US
dc.subject.meshCalcium Channel Blockers --pharmacologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshEpilepsy --drug therapyen_US
dc.subject.meshHippocampus --drug effectsen_US
dc.subject.meshHyperthermia, Induced --adverse effectsen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshMaleen_US
dc.subject.meshNifedipine --pharmacologyen_US
dc.subject.meshPhenobarbitalen_US
dc.subject.meshPhenytoinen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSeizures --drug therapyen_US
dc.titleEffect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.en_US
dc.typeJournal Articleen_US
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