Immunotoxic responses of cypermethrin, a synthetic pyrethroid insecticide in rats.

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dc.contributor.authorVarshneya, Cen_US
dc.contributor.authorSingh, Ten_US
dc.contributor.authorSharma, L Den_US
dc.contributor.authorBahga, H Sen_US
dc.contributor.authorGarg, S Ken_US
dc.date.accessioned1992-04-01en_US
dc.date.accessioned2009-06-01T07:20:35Z
dc.date.available1992-04-01en_US
dc.date.available2009-06-01T07:20:35Z
dc.date.issued1992-04-01en_US
dc.description.abstractThe study was undertaken to evaluate immunotoxic effects of cypermethrin administered orally (in ground nut oil) to male albino rats at dose levels (mg/kg) of 0 (control), 5, 10, 20 and 40 once daily for 90 days. Cypermethrin administration produced a significant leucopenia at 40 mg/kg on day 90. A dose dependent decrease (P greater than 0.05) in delayed type hypersensitivity reaction was noticed on day 61 post treatment. Humoral response as evidenced by serum haemagglutinin and haemolysin titres did not show any definite pattern on day 90. However, a significant decrease in spleen weights and significant increase in adrenal weights was recorded in rats receiving the highest test level. Total body weights and liver weights did not show any significant change with any of the dose level studied. Results of the study reveal that low doses (5 and 10 mg/kg) did not have any adverse effect on the immuno-competence of rats.en_US
dc.description.affiliationDepartment of Pharmacology and Toxicology, College of Veterinary Sciences, G. B. Pant University of Agriculture & Technology, Pantnagar.en_US
dc.identifier.citationVarshneya C, Singh T, Sharma LD, Bahga HS, Garg SK. Immunotoxic responses of cypermethrin, a synthetic pyrethroid insecticide in rats. Indian Journal of Physiology and Pharmacology. 1992 Apr; 36(2): 123-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108082
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdrenal Glands --drug effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibody Formation --drug effectsen_US
dc.subject.meshBody Weight --drug effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHemagglutinins --blooden_US
dc.subject.meshHemolysin Proteins --blooden_US
dc.subject.meshHypersensitivity, Delayeden_US
dc.subject.meshImmunity, Cellular --drug effectsen_US
dc.subject.meshImmunosuppressive Agents --toxicityen_US
dc.subject.meshInsecticides --administration & dosageen_US
dc.subject.meshLeukopenia --chemically induceden_US
dc.subject.meshMaleen_US
dc.subject.meshOrgan Size --drug effectsen_US
dc.subject.meshPyrethrins --administration & dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshSpleen --drug effectsen_US
dc.titleImmunotoxic responses of cypermethrin, a synthetic pyrethroid insecticide in rats.en_US
dc.typeJournal Articleen_US
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