Genetic components of stringent response in Vibrio cholerae.

Simple item page
dc.contributor.authorPal, Ritesh Ranjan
dc.contributor.authorDas, Bhabatosh
dc.contributor.authorDasgupta, Shreya
dc.contributor.authorBhadra, Rupak K
dc.date.accessioned2011-11-21T05:13:42Z
dc.date.available2011-11-21T05:13:42Z
dc.date.issued2011-02
dc.description.abstractNutritional stress elicits stringent response in bacteria involving modulation of expression of several genes. This is mainly triggered by the intracellular accumulation of two small molecules, namely, guanosine 3’-diphosphate 5’-triphosphate and guanosine 3’,5’-bis(diphosphate), collectively called (p)ppGpp. Like in other Gram-negative bacteria, the cellular level of (p)ppGpp is maintained in Vibrio cholerae, the causative bacterial pathogen of the disease cholera, by the products of two genes relA and spoT. However, apart from relA and spoT, a novel gene relV has recently been identified in V. cholerae, the product of which has been shown to be involved in (p)ppGpp synthesis under glucose or fatty acid starvation in a ΔrelA ΔspoT mutant background. Furthermore, the GTP binding essential protein CgtA and a non-DNA binding transcription factor DksA also seem to play several important roles in modulating stringent response and regulation of other genes in this pathogen. The present review briefly discusses about the role of all these genes mainly in the management of stringent response in V. cholerae.en_US
dc.identifier.citationPal Ritesh Ranjan, Das Bhabatosh, Dasgupta Shreya, Bhadra Rupak K. Genetic components of stringent response in Vibrio cholerae. Indian Journal of Medical Research. 2011 Feb; 133(2): 212-217.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135374
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089054/en_US
dc.subjectcgtAen_US
dc.subjectdksAen_US
dc.subject(p)ppGppen_US
dc.subjectrelAen_US
dc.subjectspoTen_US
dc.subjectstringent responseen_US
dc.subjectVibrio choleraeen_US
dc.subject.meshAmino Acid Sequence
dc.subject.meshCholera --microbiology
dc.subject.meshGene Expression Regulation, Bacterial
dc.subject.meshGenes, Bacterial
dc.subject.meshMolecular Sequence Data
dc.subject.meshSequence Alignment
dc.subject.meshVibrio cholerae --genetics
dc.subject.meshVibrio cholerae --metabolism
dc.titleGenetic components of stringent response in Vibrio cholerae.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijmr2011v133n2p212.pdf
Size:
1.39 MB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Medical Research