Trend of antibiotic resistance of Vibrio cholerae strains from East Delhi.

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dc.contributor.authorDas, Shuklaen_US
dc.contributor.authorSaha, Rumpaen_US
dc.contributor.authorKaur, Iqbal Ren_US
dc.date.accessioned2008-05-26en_US
dc.date.accessioned2009-05-27T06:31:47Z
dc.date.available2008-05-26en_US
dc.date.available2009-05-27T06:31:47Z
dc.date.issued2008-05-26en_US
dc.description.abstractBACKGROUND & OBJECTIVE: Epidemics of cholera caused by toxigenic Vibrio cholerae O1 and O139 (Bengal strain) represent a major public health problem in most developing countries. In view of the reported shift in epidemiology and pattern of antibiotic resistance in this was study carried out to assess the development of resistance to essential drugs like fluoroquinolones during treatment of cholera and cholera like cases in Delhi. METHODS: Faecal specimens collected from 1184 patients with cholera and cholera like illness between 2001-2006 admitted to Guru Teg Bahadur hospital, East Delhi were subjected to culture isolation. Antimicrobial susceptibility testing of V. cholerae isolates was done by disc diffusion method. RESULTS: Of the 1184 faecal samples examined, 670 (56.6%) were positive for V. cholera from 2001- 2006. V. cholerae El Tor Ogawa (54.6%) was more common than serotype Inaba (32.5%). During 2004-2006 V. cholerae Inaba emerged as the predominant serotype. Resistance to nalidixic acid, furazolidone and co-trimoxazole was constantly high (100%). Multiple antibiotic resistance (MAR) V. cholerae O1 Inaba isolates exhibited increased resistance to ciprofloxacin with MIC >4 microg/ml, but largely all remained susceptible to other antibiotics like, gentamicin, tetracycline and chloramphenicol. INTERPRETATION & CONCLUSION: V. cholerae have a permanent existence in the environment and during the quiescent period, their survival in water bodies allows dissipation of resistance patterns to different serotypes or strains of V. cholerae O1 and therefore there is need for constant observation.en_US
dc.description.affiliationDepartment of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Shahdara, Delhi, India. shukladas_123@yahoo.comen_US
dc.identifier.citationDas S, Saha R, Kaur IR. Trend of antibiotic resistance of Vibrio cholerae strains from East Delhi. Indian Journal of Medical Research. 2008 May; 127(5): 478-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16685
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshCholera --epidemiologyen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshDrug Resistance, Multipleen_US
dc.subject.meshFeces --microbiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshVibrio cholerae --physiologyen_US
dc.titleTrend of antibiotic resistance of Vibrio cholerae strains from East Delhi.en_US
dc.typeJournal Articleen_US
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