Functional and morphological evaluation of the meibomian glands and ocular surface assessment at high altitude

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dc.contributor.authorLi, Zhouyuen_US
dc.contributor.authorWan, Wenjuanen_US
dc.contributor.authorJi, Yanen_US
dc.contributor.authorZheng, Shijieen_US
dc.contributor.authorHu, Keen_US
dc.date.accessioned2023-08-25T06:36:42Z
dc.date.available2023-08-25T06:36:42Z
dc.date.issued2023-04
dc.description.abstractPurpose: To compare the function and morphology of the meibomian glands and the ocular surface of individuals from highland and lowland. Methods: This was a randomized controlled trial. The study was performed with 104 individuals (51 individuals from the highland and 53 individuals from the lowland). Detailed eye examinations comprising tear meniscus height, lipid layer grading, non?invasive Keratograph tear breakup time (NIKBUT), and scoring of the meibomian glands from the upper and lower eyelids of the individuals were performed by Keratograph 5M (OCULUS, Wetzlar, Germany). Symptoms related to dry eye disease were assessed using the Ocular Surface Disease Index (OSDI). Results: In the highland group, tear meniscus height was lower (P = 0.024), lipid layer grade, as well as all the meiboscores were higher (P < 0.05) than that in the lowland group. The OSDI (P = 0.018) and the percentage of dry eye disease were also higher as compared to that of the lowland group (P = 0.032). The first NIKBUT and average NIKBUT did not differ significantly between groups. The frequency of plugged meibomian gland orifices was greater in the lowland group compared to the highland group (P = 0.036). Conclusion: It was observed that dry eye disease was more common in the highland group. The morphological changes of meibomian gland dropout were significant in highlanders as demonstrated objectively with Keratograph 5M. Our study may raise a concern for environmental influences on ocular surface changesen_US
dc.identifier.affiliationsThe First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, Chinaen_US
dc.identifier.citationLi Zhouyu, Wan Wenjuan, Ji Yan, Zheng Shijie, Hu Ke. Functional and morphological evaluation of the meibomian glands and ocular surface assessment at high altitude. Indian Journal of Ophthalmology. 2023 Apr; 71(4): 1483-1487en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224952
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber4en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_2657_22en_US
dc.subjectDry eye diseaseen_US
dc.subjecthigh altitudeen_US
dc.subjectmeibomian glandsen_US
dc.subjectocular surfaceen_US
dc.titleFunctional and morphological evaluation of the meibomian glands and ocular surface assessment at high altitudeen_US
dc.typeJournal Articleen_US
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