Normative Data of Infant Pulmonary Function Testing: A Prospective Birth Cohort Study from India

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dc.contributor.authorKumar, Prawinen_US
dc.contributor.authorMukherjee, Aparnaen_US
dc.contributor.authorRandev, Shivanien_US
dc.contributor.authorJat, Kana Ramen_US
dc.contributor.authorLodha, Rakeshen_US
dc.contributor.authorKabra, Sushil Ken_US
dc.date.accessioned2020-04-23T07:45:03Z
dc.date.available2020-04-23T07:45:03Z
dc.date.issued2020-01
dc.description.abstractObjective: To develop a normal reference range of Infantpulmonary function test (IPFT) indices for Indian children.Design: Prospective birth cohort study.Setting: Division of Pediatric Pulmonology of a tertiary-careinstitute in India from August 2012 to March 2017.Participants: All neonates born at the institute during the studyperiod were screened for eligibility.Measurement: IPFT at baseline and every 6-month until 36-months of age.Main Outcome Measure(s): Tidal breathing flow-volume loop(TBFVL), Rapid thoracoabdominal compression (RTC), andRaised volume RTC (RVRTC) indices at baseline and follow-up.Results: 310 newborns were enrolled in the cohort; 281 of them(169 male) had completed 36-months of follow-up at the end ofthe study period. There was no influence of gender on thebaseline IPFT indices. Tidal volume per unit body weight (VT/kg)significantly increased from baseline to 36 months of age(P<0.001) while the peak ratio (tPTEF/tE) initially decreased in first18-months of age (P<0.001), after that returned to the baselinevalue by 36 months of age. RTC indices did not changesignificantly from baseline values. In RVRTC, the ratio of forcedexpiratory volume in 0.5s to forced vital capacity (FEV0.5/FVC)was significantly decreased from baseline to 36 months of age(P=0.002).Conclusions: Normal values for various IPFT indices for TBFVL,RTC, and RVRTC from neonates to the age of 36-month areprovided. These data may be used as normative data for healthyneonates and children of Indian originen_US
dc.identifier.affiliationsDepartment of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.en_US
dc.identifier.citationKumar Prawin, Mukherjee Aparna, Randev Shivani, Jat Kana Ram, Lodha Rakesh, Kabra Sushil K. Normative Data of Infant Pulmonary Function Testing: A Prospective Birth Cohort Study from India. Indian Pediatrics. 2020 Jan; 57(1): 25-33en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199495
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber1en_US
dc.relation.volume57en_US
dc.source.urihttps://www.indianpediatrics.net/jan2020/25.pdfen_US
dc.subjectIndicesen_US
dc.subjectRapid thoracoabdominal compressionen_US
dc.subjectTidalbreathing flow-volume loopen_US
dc.titleNormative Data of Infant Pulmonary Function Testing: A Prospective Birth Cohort Study from Indiaen_US
dc.typeJournal Articleen_US
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