Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study

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dc.contributor.authorYaqoob, Irfanen_US
dc.contributor.authorTramboo, Nisar A.en_US
dc.contributor.authorBhat, Irfan A.en_US
dc.contributor.authorPandith, Arshaden_US
dc.contributor.authorBeig, Jahangir R.en_US
dc.contributor.authorHafeez, Imranen_US
dc.contributor.authorLone, Aijaz A.en_US
dc.contributor.authorShah, Tariq R.en_US
dc.contributor.authorSamreen, Sumeraen_US
dc.date.accessioned2020-01-02T06:41:09Z
dc.date.available2020-01-02T06:41:09Z
dc.date.issued2018-01
dc.description.abstractBackground The role of polymorphism of Angiotensin converting enzyme (ACE) gene and ACE activity in etiopathogenesis, prognosis, and many other clinical parameters in the various form of the cardiovascular disease has been established to some degree of certainty. The pathophysiology of Peripartum cardiomyopathy (PPCM) remains an area of active research. The main aim of our study was to see pattern of ACE- Insertion/Deletion (I/D) allele in PPCM and its implications on left ventricular performance indices. Methods This single-center case-control study included 45 cases and 70 controls. The diagnosis of PPCM was established clinically and echocardiographically. ACE genotyping was done by polymerase chain reaction (PCR) method in all subjects. Results The II, ID, and DD genotype was present in 16, 18 and 11 of subjects with PPCM and 48, 19 and 3 of controls respectively. The odds ratio for ACE-II genotype in cases vs. controls was 0.253 (95% CI = 0.114–0.558; p = 0.007), for that of II genotype was 1.93 (95% CI = 0.86–4.3; p = 0.107) and for DD genotype was 7.225 (95% CI; 1.88–27.6; p = 0.0039). Overall frequency of D allele in cases was significantly higher than controls (odds = 4.25; 95% CI = 2.01–6.7; p = 0.0001). Moreover, ejection fraction, left ventricular volume and linear dimensions were worse in patients with DD genotype. Conclusion ACE DD genotype and overall frequency of D allele is significantly higher in patients with PPCM. Also, the presence of DD genotype is associated with worse systolic performance indices measured echocardiographically.en_US
dc.identifier.affiliationsDep’t. of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Indiaen_US
dc.identifier.affiliationsDep’t. Of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Indiaen_US
dc.identifier.affiliationsDep’t. of Cardiology, Government Medical College, Srinagar, Indiaen_US
dc.identifier.citationYaqoob Irfan, Tramboo Nisar A., Bhat Irfan A., Pandith Arshad, Beig Jahangir R., Hafeez Imran, Lone Aijaz A., Shah Tariq R., Samreen Sumera. Insertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control study. Indian Heart Journal. 2018 Jan; 70(1): 66-70en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/191742
dc.languageenen_US
dc.publisherCardiological Society of Indiaen_US
dc.relation.issuenumber1en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2017.05.020en_US
dc.subjectPeripartum cardiomyopathyen_US
dc.subjectHeart failureen_US
dc.subjectAngiotensin converting enzyme geneen_US
dc.subjectEchocardiographyen_US
dc.titleInsertion/deletion polymorphism of ACE gene in females with peripartum cardiomyopathy: A case-control studyen_US
dc.typeJournal Articleen_US
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