Comparison of Oral Ivabradine, Oral Metoprolol and Placebo to Attenuate the Stress Response in Nasal and Laryngeal Surgeries: A Prospective, Randomized, Double Blind Study

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dc.contributor.authorMathur, Vijayen_US
dc.contributor.authorGodara, Ankiten_US
dc.contributor.authorJethawa, Durgaen_US
dc.contributor.authorSharma, S.Pen_US
dc.contributor.authorVerma, Kalpanaen_US
dc.date.accessioned2020-09-24T07:24:49Z
dc.date.available2020-09-24T07:24:49Z
dc.date.issued2019-03
dc.description.abstractIntroduction: Nasal surgeries like septoplasty, polypectomyand laryngeal surgeries for removal of vocal nodule, cysts etcare commonly performed. Changes in haemodynamics due tolaryngoscopy and endotracheal intubation are likely to persistduring these procedures. These surgeries also require bloodless field. The present study was conducted to evaluate andcompare the efficacy of oral metoprolol tartrate versus oralivabradine versus placebo in attenuation of haemodynamicresponses during laryngoscopy, tracheal intubation andthroughout nasal and laryngeal surgeries.Methods: This was a prospective, randomized, comparative,double blind study. . Patients were randomly allocated bysimple randomization into 3 groups having 30 patients in each.Neither the patient nor the investigator was aware, whichpatient is allocated into which group and were unaware of thedrug being administered as it was given to the patient by aperson not involved in the study. Data collections were carriedout by investigator in a double blind manner. All the patientswere explained about the anesthesia technique and writteninformed consent was taken. Group 1: Oral Ivabradine 5mgtablet was given orally 2 hours before induction of anaesthesia.Group 2: Oral Metoprolol tartrate 50mg tablet was given orally2 hours before induction of anaesthesia. Group 3: Oral placebowas given 2 hours before induction of anaesthesia.Results and Conclusion: We concluded that both the drugscan be used as an effective premedication, to attenuate thesympathetic response to laryngoscopy, endotrachealintubation, extubation and throughout nasal and laryngealsurgeries. However Metopolol was found to have better controlthan Ivabradine in maintaining the vitals at all points andproviding a good hypotensive effect than ivabradine.en_US
dc.identifier.affiliationsProfessor, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsJunior Resident, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsProfessor and HOD, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Anaesthesiology, Critical Care and Pain Management, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, Indiaen_US
dc.identifier.citationMathur Vijay, Godara Ankit, Jethawa Durga, Sharma S.P, Verma Kalpana. Comparison of Oral Ivabradine, Oral Metoprolol and Placebo to Attenuate the Stress Response in Nasal and Laryngeal Surgeries: A Prospective, Randomized, Double Blind Study. International Journal of Medical Research Professionals. 2019 Mar; 5(2): 115-123en_US
dc.identifier.issn2454-6364
dc.identifier.issn2454-6356
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203128
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume5en_US
dc.source.urihttps://ijmrp.com/Admin_Portal/Upload/Vol5Issue2/25%20IJMRP%205(2)%20115-23.pdfen_US
dc.subjectIvabradineen_US
dc.subjectMetoprololen_US
dc.subjectStress Responseen_US
dc.subjectNasal and Laryngeal Surgeries.en_US
dc.titleComparison of Oral Ivabradine, Oral Metoprolol and Placebo to Attenuate the Stress Response in Nasal and Laryngeal Surgeries: A Prospective, Randomized, Double Blind Studyen_US
dc.typeJournal Articleen_US
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