Assessing The Potential Value of KI-67 in Predicting the Therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer Patients in Indian Population and to Determine the Best Ki-67 Cutoff Value that Increases the Prediction Accuracy in Making Treatment Decisions

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dc.contributor.authorNaz, Aen_US
dc.contributor.authorSarkar, DKen_US
dc.contributor.authorBasu, Sen_US
dc.contributor.authorDas, AKen_US
dc.contributor.authorRoy, PK.en_US
dc.date.accessioned2025-05-12T08:15:07Z
dc.date.available2025-05-12T08:15:07Z
dc.date.issued2024-12
dc.description.abstractObjective: To assess the potential value of Ki-67 in predicting the therapeutic response to neoadjuvant chemotherapy in breast cancer patients in the Indian population and to determine the best Ki-67 cutoff value that increases the prediction accuracy in making treatment decisions. Materials and Methods: This is a prospective observational study where breast cancer patients who underwent MRM/BCS surgery after neoadjuvant chemotherapy at SSKM and IPGMER Hospital between January 2024 and September 2024 in 50 patients. The clinical and pathologic characteristics of all patients were obtained from the hospital medical records. The clinical and pathological response to chemotherapy was determined. Result: As a result of the analysis from this study, clinical and pathological responses to NST were significantly improved when Ki-67 levels were high >17% (P = 0.05). Furthermore, a better rate of pathological complete response (pCR) was significantly associated with tumor size <5 cm (P = 0.02), and vascular invasion when positive (P = 0.023). Conclusion: Clinical and pathological responses to NST were significantly improved when Ki-67 levels were high >17. Furthermore, a better rate of pCR was significantly associated with tumor size <5 cm, and vascular invasion when positive. Our analysis showed that a Ki-67 cutoff >17% predicted a better pCR rate.en_US
dc.identifier.affiliationsPost Doctorate Breast Fellow, Department of General Surgery in IPGMER and SSKM Hospital, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsProfessor and Head, Department of the Comprehensive Breast Clinic, IPGMER and SSKM Hospital, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsPost Doctorate Breast Fellow, Department of General Surgery in IPGMER and SSKM Hospital, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of General Surgery in IPGMER and SSKM Hospital, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of General Surgery in Malda Medical College and Hospital, Malda, West Bengal, Indiaen_US
dc.identifier.citationNaz A, Sarkar DK, Basu S, Das AK, Roy PK. . Assessing The Potential Value of KI-67 in Predicting the Therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer Patients in Indian Population and to Determine the Best Ki-67 Cutoff Value that Increases the Prediction Accuracy in Making Treatment Decisions. International Journal of Scientific Study. 2024 Dec; 12(9): 23-28en_US
dc.identifier.issn2321-6379
dc.identifier.issn2321-595X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246957
dc.languageenen_US
dc.publisherInternational Research Organization for Life & Health Sciencesen_US
dc.relation.issuenumber9en_US
dc.relation.volume12en_US
dc.source.urihttps://www.ijss-sn.com/uploads/2/0/1/5/20153321/03_ijss_dec_24_oa01_-_2024.pdfen_US
dc.subjectBreast canceren_US
dc.subjectKi-67en_US
dc.subjectNeoadjuvant chemotherapyen_US
dc.subjectTumor sizeen_US
dc.titleAssessing The Potential Value of KI-67 in Predicting the Therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer Patients in Indian Population and to Determine the Best Ki-67 Cutoff Value that Increases the Prediction Accuracy in Making Treatment Decisionsen_US
dc.typeJournal Articleen_US
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