Red cell pyruvate kinase deficiency in neonatal jaundice cases in India.

Simple item page
dc.contributor.authorKedar, Prabhakar Sen_US
dc.contributor.authorWarang, Prashanten_US
dc.contributor.authorColah, Roshan Ben_US
dc.contributor.authorMohanty, Dipikaen_US
dc.date.accessioned2006-11-28en_US
dc.date.accessioned2009-05-30T11:07:24Z
dc.date.available2006-11-28en_US
dc.date.available2009-05-30T11:07:24Z
dc.date.issued2006-11-28en_US
dc.description.abstractOBJECTIVE: Pyruvate Kinase (PK) deficiency is the most common enzymopathy of the glycolytic pathway in erythrocytes. It constitutes one of the common causes of hereditary non-spherocytic hemolytic anemia. The aim of this study was to screen newborns in India for pyruvate kinase (PK) deficiency in relation to unconjugated hyperbilirubinemia. METHODS: Laboratory investigations done included complete blood counts, reticulocyte counts, direct and indirect bilirubin, assay of G6PD and PK activity, ATP and 2,3 DPG levels. All variables were studied in 50-cord blood samples from normal deliveries and 218 neonates with hyperbilirubinemia. RESULTS: 7 of the 218 cases of neonatal jaundice were PK deficient with 30-40% reduction in PK activity. These cases also had a 3-4-fold increase in 2,3 DPG:ATP ratios, which is one of the additional indicators for PK deficiency. Six of the 7 infants had a severe clinical course. CONCLUSION: This study shows that the prevalence of PK deficiency in Indian neonatal jaundice cases is 3.21%, which is relatively high. This emphasizes the need for screening neonatal hyperbilirubinemia cases in India for PK deficiency.en_US
dc.description.affiliationInstitute of Immunohaematology, Indian Council of Medical Research, K.E.M. Hospital Campus, Parel, Mumbai, India.en_US
dc.identifier.citationKedar PS, Warang P, Colah RB, Mohanty D. Red cell pyruvate kinase deficiency in neonatal jaundice cases in India. Indian Journal of Pediatrics. 2006 Nov; 73(11): 985-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/79352
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshErythrocytes --enzymologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshJaundice, Neonatal --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMetabolism, Inborn Errors --blooden_US
dc.subject.meshPyruvate Kinase --deficiencyen_US
dc.titleRed cell pyruvate kinase deficiency in neonatal jaundice cases in India.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Pediatrics