Potential of radiosensitizing agents in cancer chemo-radiotherapy.

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dc.contributor.authorGirdhani, Sen_US
dc.contributor.authorBhosle, S Men_US
dc.contributor.authorThulsidas, S Aen_US
dc.contributor.authorKumar, Aen_US
dc.contributor.authorMishra, K Pen_US
dc.date.accessioned2005-07-14en_US
dc.date.accessioned2009-06-01T16:16:55Z
dc.date.available2005-07-14en_US
dc.date.available2009-06-01T16:16:55Z
dc.date.issued2005-07-14en_US
dc.description20 references.en_US
dc.description.abstractPotential of herbs and other plant-based formulations have been increasingly recognized in prevention and treatment of human diseases including cancer. There exist enormous prospect for screening and evaluation of herbal/plant products for developing effective radiosensitization and radioprotection relevant to nuclear research program. Investigations in our laboratory have focused on the mechanism of activity of variety of anticancer and antioxidant agents, namely, Eugenol, (EU), Ellagic acid (EA), Triphala (TPL), Tocopherol Succinate (TOS) and Arachidonic acid on normal and cancer cells with view to design effective protocols in practical radioprotection and cancer radiotherapy. This paper is mainly focused on studies on cytotoxic effects on cancer cell lines. Results have shown that these agents produced radiosensitizing action involving oxidative damage, membrane alteration and damage to nucleic acid in various human cell lines. Studies were performed employing fluorescence probes and electron spin resonance methods and gel electrophoresis protocols. It has been found that cytotoxic effect was induced by initiating membrane oxidative damage and by triggering intracellular generation of reactive oxygen species (ROS) by gamma radiation in combination with phytochemicals like TPL, EA and TOS in tumor cell line Ehrlich Ascites (EAC), Human cervical (HeLa) and breast (MCF-7) cells. Membrane damage and ROS generation was measured by DPH and DCF-FDA fluorescent probes respectively after exposure to low to moderate doses of gamma radiation. This talk will present the cytotoxic effects of phytochemicals in combination with ionizing radiation. It is emphasized that modulation of membrane peroxidative damage and intra cellular ROS may help achieve efficient killing of cancer cells which may provide a new approach to developing effective treatment of cancer.en_US
dc.description.affiliationRadiation Biology and Health Sciences Division Bhabha Atomic Research Centre, Mumbai 400 085, India.en_US
dc.identifier.citationGirdhani S, Bhosle SM, Thulsidas SA, Kumar A, Mishra KP. Potential of radiosensitizing agents in cancer chemo-radiotherapy. Journal of Cancer Research and Therapeutics. 2005 Jul-Sep; 1(3): 129-31en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111438
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshApoptosisen_US
dc.subject.meshArachidonic Acid --therapeutic useen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshEllagic Acid --therapeutic useen_US
dc.subject.meshEugenol --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshNeoplasms --metabolismen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRadiation-Sensitizing Agents --therapeutic useen_US
dc.subject.meshReactive Oxygen Species --metabolismen_US
dc.subject.meshTocopherolsen_US
dc.subject.meshVitamin E --analogs & derivativesen_US
dc.titlePotential of radiosensitizing agents in cancer chemo-radiotherapy.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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