Effect of vitamin A supplementation on childhood morbidity and mortality: critical review of Indian studies.

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dc.contributor.authorGupta, Piyushen_US
dc.contributor.authorIndrayan, Abhayaen_US
dc.date.accessioned2002-12-11en_US
dc.date.accessioned2009-05-27T05:00:39Z
dc.date.available2002-12-11en_US
dc.date.available2009-05-27T05:00:39Z
dc.date.issued2002-12-11en_US
dc.description.abstractOBJECTIVE: To review all published randomized trials concerned with linkage of vitamin A supplementation with reduction of mortality and morbidity in Indian children. METHOD: The studies were identified by searching the PubMed, review articles, references of available meta-analyses and bibliography of pertinent references. Studies were extracted and the quality of each study was reviewed with regards to 10 categories of parameters that in our opinion, were important for a vitamin A prophylaxis trial. These included background indicators, subjects, design, intervention, proximal measures, field-work, sources of bias, data analysis, interpretation and documentation. RESULTS: Out of 12 studies satisfying the inclusion criteria, the available 11 were examined. Two of the trials were concerned with mortality, 6 with morbidity, and 2 with both mortality and morbidity; 1 study assessed the impact of vitamin A on pneumococcal colonization. Out of 4 mortality trials, only one could satisfactorily report a significant reduction (54 percent) in child mortality following vitamin A supplementation. Of 8 morbidity studies, only 3 indicated some beneficial effect of vitamin A supplementation. None of the studies was perfect in methodology. We could not locate any study that addressed the issue of cost-effectiveness or dietary modifications. The results were not unequivocal and findings for mortality and morbidity were not corroborative. CONCLUSION: There is no definite evidence as yet in favor or against substantial benefit of universal vitamin A supplementation to children in India. There is a clear need to undertake a comprehensive trial with adequate sample size and a standardized methodology that could give clear, unbiased, and convincing evidence on the role of routine vitamin A supplementation.en_US
dc.description.affiliationDepartment of Pediatrics, University College of Medical Sciences and GTB Hospital, Delhi 110 095, India. drpiyush@satyam.net.inen_US
dc.identifier.citationGupta P, Indrayan A. Effect of vitamin A supplementation on childhood morbidity and mortality: critical review of Indian studies. Indian Pediatrics. 2002 Dec; 39(12): 1099-118en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/7340
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshChilden_US
dc.subject.meshDietary Supplementsen_US
dc.subject.meshEvidence-Based Medicineen_US
dc.subject.meshHumansen_US
dc.subject.meshMorbidityen_US
dc.subject.meshRandomized Controlled Trials as Topicen_US
dc.subject.meshVitamin A --therapeutic useen_US
dc.titleEffect of vitamin A supplementation on childhood morbidity and mortality: critical review of Indian studies.en_US
dc.typeJournal Articleen_US
dc.typeMeta-Analysisen_US
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