Lymphocytotoxic antibodies & immunity in pulmonary tuberculosis.

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dc.contributor.authorUma, Hen_US
dc.contributor.authorSelvaraj, Pen_US
dc.contributor.authorReetha, A Men_US
dc.contributor.authorXavier, Ten_US
dc.contributor.authorPrabhakar, Ren_US
dc.contributor.authorNarayanan, P Ren_US
dc.date.accessioned1999-01-18en_US
dc.date.accessioned2009-05-27T08:15:23Z
dc.date.available1999-01-18en_US
dc.date.available2009-05-27T08:15:23Z
dc.date.issued1999-01-18en_US
dc.description.abstractTo understand whether the presence of cold reactive lymphocytotoxic antibodies (LCA) (reactive at 15 degrees C) in the system has any effect on immunity to tuberculosis lymphocytotoxic antibodies to adherent cells (enriched-B cells) and non-adherent cells were studied in active-TB (n = 42) and inactive-TB (cured) patients (n = 49) and healthy controls (n = 32). The plasma samples of inactive-TB patients showed higher percentage of positivity for lymphocytotoxic antibodies (36.7%) than the active-TB patients (21.4%) and control subjects (18.8%). No significant difference on antibody and lymphocyte response against Mycobacterium tuberculosis culture filtrate antigens was observed between LCA positive and LCA negative active-TB patients and normal healthy controls. Further, determination of HLA-DR phenotype of the patients and control subjects showed that individuals positive for lymphocytotoxic antibodies were more among HLA-DR2 positive and DR7 positive active-TB patients and control subjects than non-DR2 and non-DR7 subjects. The present study suggests that the cold reactive lymphocytotoxic antibodies may be against B-lymphocytes and persistent for a longer time. HLA-DR2 and -DR7 may be associated with the occurrence of LCA activity. Further, the presence of LCA has no immunoregulatory role on immunity to tuberculosis.en_US
dc.description.affiliationTuberculosis Research Center (ICMR), Chennai.en_US
dc.identifier.citationUma H, Selvaraj P, Reetha AM, Xavier T, Prabhakar R, Narayanan PR. Lymphocytotoxic antibodies & immunity in pulmonary tuberculosis. Indian Journal of Medical Research. 1999 Jan; 109(): 5-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23799
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAntilymphocyte Serum --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHLA-DR Antigens --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTuberculosis, Pulmonary --immunologyen_US
dc.titleLymphocytotoxic antibodies & immunity in pulmonary tuberculosis.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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