Lipid peroxidation, hemolysis and antioxidant enzymes of erythrocytes in stroke.

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dc.contributor.authorSudha, Ken_US
dc.contributor.authorRao, Ashalatha Ven_US
dc.contributor.authorRao, Suryanarayanaen_US
dc.contributor.authorRao, Anjalien_US
dc.date.accessioned2004-04-04en_US
dc.date.accessioned2009-06-01T06:25:23Z
dc.date.available2004-04-04en_US
dc.date.available2009-06-01T06:25:23Z
dc.date.issued2004-04-04en_US
dc.description.abstractErythrocyte membrane lipid peroxidation and consequent percentage hemolysis and related antioxidant enzymes viz., superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase were determined in 16 cases of hemorrhagic stroke and 30 cases of thrombotic stroke. The results obtained were compared with 50 age and sex matched controls. 12 thrombotic stroke patients who showed symptomatic recovery after medication were considered for follow up. Lipid peroxidation and percentage hemolysis in patients with thrombotic stroke and hemorrhagic stroke was significantly elevated when compared to controls. Glutathione reductase and superoxide dismutase levels were found to be significantly reduced in thrombotic stroke and hemorrhagic stroke respectively, when compared to healthy subjects. There was no significant difference in the other parameters when compared to controls. In post treatment thrombotic stoke, catalase and glutathione reductase levels increased significantly and oxidative hemolysis decreased compared to their pretreatment values. Thus, our results indicate considerable oxidative stress in stroke.en_US
dc.description.affiliationDepartment of Biochemistry, Kasturba Medical College, Mangalore-575 001.en_US
dc.identifier.citationSudha K, Rao AV, Rao S, Rao A. Lipid peroxidation, hemolysis and antioxidant enzymes of erythrocytes in stroke. Indian Journal of Physiology and Pharmacology. 2004 Apr; 48(2): 199-205en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107374
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAntioxidants --metabolismen_US
dc.subject.meshErythrocytes --enzymologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHemolysis --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLipid Peroxidation --physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshStroke --blooden_US
dc.titleLipid peroxidation, hemolysis and antioxidant enzymes of erythrocytes in stroke.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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