Interpretation of treadmill stress test in patients with coronary artery disease receiving beta blocker therapy.

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dc.contributor.authorSrivastava, S Cen_US
dc.contributor.authorKatyal, V Ken_US
dc.contributor.authorJagdish,en_US
dc.contributor.authorGupta, Sen_US
dc.contributor.authorMohan, Ren_US
dc.date.accessioned1991-02-01en_US
dc.date.accessioned2009-05-30T20:41:45Z
dc.date.available1991-02-01en_US
dc.date.available2009-05-30T20:41:45Z
dc.date.issued1991-02-01en_US
dc.description.abstractGraded maximal treadmill exercise responses were studied before and after beta blockade (atenolol 100 mg once daily for 2 weeks) in 20 male patients with chronic stable angina. Beta-blocking effect consisted of significant reduction of resting heart rate (HR) by 21%, systolic blood pressure (SBP) by 12% and rate pressure product (RPP) by 30%. While the maximum exercise capacity was marginally increased by mean 1.7 min +/- 1.6 SD (P less than 0.001) under the influence of therapy, peak HR, SBP and maximum RPP were significantly lower (P less than 0.001) than in preatenolol exercise tests. Similarly, while the configuration and magnitude of ST segment depression did not differ materially between the pre and post atenolol tests, onset time of ST change was delayed and offset time shortened significantly. These parameters cannot be relied upon to assess the extent and severity of coronary artery disease (CAD) if stress test is carried out while the patient is on a beta-blocking drug. The overall sensitivity of the stress test to detect coronary disease is, however, not likely to be compromised because of negligible influence of beta-blockers upon ST segment depression provided maximally tolerated (not submaximal) exercise is performed. ST/HR slope, an exercise test variable known to correlate well with the extent of CAD, was shown to be uninfluenced by beta-blockade. Its measurement is therefore recommended in interpreting stress tests performed in patients receiving beta-blocker therapy. This, however, requires a meticulously prepared protocol of recording computer averaged QRST complexes and multilead ECG tracings at very frequent intervals throughout the exercise.(ABSTRACT TRUNCATED AT 250 WORDS)en_US
dc.description.affiliationDepartment of Medicine, Medical College and Hospital, Rohtak, Haryana.en_US
dc.identifier.citationSrivastava SC, Katyal VK, Jagdish , Gupta S, Mohan R. Interpretation of treadmill stress test in patients with coronary artery disease receiving beta blocker therapy. Journal of the Association of Physicians of India. 1991 Feb; 39(2): 186-90en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/87936
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAtenolol --therapeutic useen_US
dc.subject.meshCoronary Disease --diagnosisen_US
dc.subject.meshElectrocardiography --drug effectsen_US
dc.subject.meshExercise Test --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleInterpretation of treadmill stress test in patients with coronary artery disease receiving beta blocker therapy.en_US
dc.typeJournal Articleen_US
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