Viability of Mycobacterium leprae in the environment and its role in leprosy dissemination.

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dc.contributor.authorMohanty, Partha Sarathi
dc.contributor.authorNaaz, Farah
dc.contributor.authorKatara, Dheeraj
dc.contributor.authorMisba, Lama
dc.contributor.authorKumar, Dilip
dc.contributor.authorDwivedi, Deepak Kumar
dc.contributor.authorTiwari, Amit Kumar
dc.contributor.authorChauhan, Devendra Singh
dc.contributor.authorBansal, Avi Kumar
dc.contributor.authorTripathy, Srikanth Prasad
dc.contributor.authorKatoch, Kiran
dc.date.accessioned2016-01-06T07:24:09Z
dc.date.available2016-01-06T07:24:09Z
dc.date.issued2016-01
dc.description.abstractBackground: Leprosy, a chronic disease caused by Mycobacterium leprae, is a public health concern in certain countries, including India. Although the prevalence of the disease has fallen drastically over time, new cases continue to occur at nearly the same rate in many regions. Several endemic pockets have been observed in India and elsewhere. The precise dynamics of leprosy transmission are still not clearly understood. Both live bacilli as well as M. leprae DNA have been detected in the soil and water of endemic areas; they possibly play an important role in disease transmission. Aims: To study the occurrence of viable M. leprae in environmental samples collected from areas of residence of patients with active leprosy. Methods: The study was conducted on 169 newly diagnosed leprosy patients in Ghatampur, Uttar Pradesh, India. Soil and water samples were collected from their areas of residence using a standardized protocol. An equal number of soil and water samples were also collected from non-patient areas of the same or adjoining villages. The environmental samples collected from the patients surroundings were subjected to 16S ribosomal RNA gene analysis after obtaining informed consent. Results: About a quarter of the environmental samples collected from patient areas, (25.4% of soil samples and 24.2% of water samples) were found to be positive for specifi c 16S ribosomal RNA genes of M. leprae. Environmental samples collected from non-patient areas were all found negative for M. leprae 16S ribosomal RNA genes. Limitations: The major limitation of the study was that the sample size was small. Conclusion: The study demonstrated the presence of viable strains of M. leprae in skin smear samples of paucibacillary patients and multibacillary patients, as well as in the environmental samples obtained from around their houses. This could play an important role in the continued transmission of leprosy.en_US
dc.identifier.citationMohanty Partha Sarathi, Naaz Farah, Katara Dheeraj, Misba Lama, Kumar Dilip, Dwivedi Deepak Kumar, Tiwari Amit Kumar, Chauhan Devendra Singh, Bansal Avi Kumar, Tripathy Srikanth Prasad, Katoch Kiran. Viability of Mycobacterium leprae in the environment and its role in leprosy dissemination. Indian Journal of Dermatology, Venereology and Leprology. 2016 Jan-Feb; 82(1): 23-27.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/169969
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2016;volume=82;issue=1;spage=23;epage=27;aulast=Mohantyen_US
dc.subject16S ribosomal RNAen_US
dc.subjectleprosyen_US
dc.subjectmultibacillaryen_US
dc.subjectMycobacterium lepraeen_US
dc.subjectpaucibacillaryen_US
dc.titleViability of Mycobacterium leprae in the environment and its role in leprosy dissemination.en_US
dc.typeArticleen_US
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