Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype.

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dc.contributor.authorGadage, Vijaya
dc.contributor.authorKembhavi, Seema
dc.contributor.authorKumar, Prabhash
dc.contributor.authorShet, Tanuja
dc.date.accessioned2012-10-11T10:16:31Z
dc.date.available2012-10-11T10:16:31Z
dc.date.issued2011-07
dc.description.abstractPrimary cardiac lymphoma (PCL) is a rare and fatal disorder. It may often mimic other common cardiac tumors like cardiac myxoma because of similarities in the clinical presentation. We report a case of PCL of diffuse large B-cell type, in a 38-year-old, immunocompetent male who presented with superior vena cava syndrome that was excised as a myxoma. Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype. After four cycles of Rituximab with CHOP (cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisolone) the tumor regressed completely but the patient had a relapse and subsequently succumbed to the disease confirming the aggressive nature. The aggressive behavior of PCL may be possibly linked to its ABC-like origin.en_US
dc.identifier.citationGadage Vijaya, Kembhavi Seema, Kumar Prabhash, Shet Tanuja. Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype. Indian Journal of Pathology & Microbiology. 2011 Jul-Sept 54(3): 591-593.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142052
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=591;epage=593;aulast=Gadageen_US
dc.subjectCardiac tumoren_US
dc.subjectdiffuse large B-cell lymphomaen_US
dc.subjectnon-Hodgkin′s lymphomaen_US
dc.subject.meshAdult
dc.subject.meshAntibodies, Monoclonal, Murine-Derived --administration & dosage
dc.subject.meshAntigens, CD20 --biosynthesis
dc.subject.meshAntigens, CD45 --biosynthesis
dc.subject.meshAntineoplastic Agents --administration & dosage
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --administration & dosage
dc.subject.meshB-Lymphocytes --immunology
dc.subject.meshCyclophosphamide --administration & dosage
dc.subject.meshDoxorubicin --administration & dosage
dc.subject.meshFatal Outcome
dc.subject.meshForkhead Transcription Factors --biosynthesis
dc.subject.meshGene Expression Profiling
dc.subject.meshHeart Neoplasms --complications
dc.subject.meshHeart Neoplasms --diagnosis
dc.subject.meshHeart Neoplasms --drug therapy
dc.subject.meshHeart Neoplasms --pathology
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshInterferon Regulatory Factors --biosynthesis
dc.subject.meshLymphoma, B-Cell --complications
dc.subject.meshLymphoma, B-Cell --diagnosis
dc.subject.meshLymphoma, B-Cell --drug therapy
dc.subject.meshLymphoma, B-Cell --pathology
dc.subject.meshMale
dc.subject.meshMicroscopy
dc.subject.meshPhenotype
dc.subject.meshPrednisone --administration & dosage
dc.subject.meshRadiography, Thoracic
dc.subject.meshRecurrence
dc.subject.meshRepressor Proteins --biosynthesis
dc.subject.meshSuperior Vena Cava Syndrome --diagnosis
dc.subject.meshSuperior Vena Cava Syndrome --pathology
dc.subject.meshTomography, X-Ray Computed
dc.subject.meshTreatment Outcome
dc.subject.meshVincristine --administration & dosage
dc.titlePrimary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype.en_US
dc.typeArticleen_US
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