Immunogenicity of hepatitis B vaccine in premature infants.

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dc.contributor.authorSanpavat, Sen_US
dc.contributor.authorPoovorawan, Yen_US
dc.contributor.authorChittinand, Sen_US
dc.contributor.authorBhongsvej, Sen_US
dc.contributor.authorThaithumyanon, Pen_US
dc.date.accessioned2009-05-27T15:16:25Z
dc.date.available2009-05-27T15:16:25Z
dc.date.issued1994-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe immunogenicity of plasma-derived hepatitis B vaccine was studied in 39 premature neonates, whose weights were 1,800-2,400 g and gestational ages 32-37 weeks. All maternal antiHBc antibody were negative. Dosage of 5 micrograms of hepatitis B vaccine (Pasteur vaccine) was given at 0, 1, 2 and 12 months after birth. At the ages of 1, 2, 4, 9, 12 and 13 months, antiHBs antibody was found in 7.7%, 20%, 69.7%, 81.4%, 77.3% and 89.5%, respectively, while the geometric mean titer in this seropositive group, starting at age 2 months was 37, 121, 113, 69 and 1,016 mIU/ml. There was no severe reaction attributed to the vaccination. The result indicated that the vaccine was immunogenic. Although the conversion rate was low after primary injection, a satisfactory response developed at age 4 months after 3 doses of vaccine.en_US
dc.description.affiliationDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.en_US
dc.identifier.citationSanpavat S, Poovorawan Y, Chittinand S, Bhongsvej S, Thaithumyanon P. Immunogenicity of hepatitis B vaccine in premature infants. The Southeast Asian Journal of Tropical Medicine and Public Health. 1994 Mar; 25(1): 93-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32363
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshBirth Weighten_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHepatitis B Antibodies --blooden_US
dc.subject.meshHepatitis B Vaccines --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization Scheduleen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInfant, Premature --blooden_US
dc.subject.meshMaleen_US
dc.titleImmunogenicity of hepatitis B vaccine in premature infants.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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