Measurement of vitamin D and cathelicidin (LL-37) levels in patients of psoriasis with co-morbidities.

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dc.contributor.authorAl-Mutairi, Nawaf
dc.contributor.authorEassa, Bayoumi EL
dc.contributor.authorNair, Vasanthy
dc.date.accessioned2013-07-25T04:42:58Z
dc.date.available2013-07-25T04:42:58Z
dc.date.issued2013-07
dc.description.abstractBackground: During the last decade, a lot of co-morbidities (diabetes, obesity, heart disease, etc.) have been described to be associated with psoriasis, but the exact link at the molecular level is not well-known. Researchers have shown molecular level changes in vitamin D pathway and its relationship to cathelicidin. Aims: To estimate the levels of cathelicidin (LL-37), and vitamin D in psoriasis patients with co-morbidities, and compare them with matched healthy controls. Methods: One hundred consecutive patients with stable plaque psoriasis (psoriasis area and severity index ≥10) with no systemic treatment in the past 3 months were investigated for the serum levels of vitamin D and LL-37, and compared with equal number of matched healthy volunteers. Results: The serum vitamin D levels were significantly lower in patients. Furthermore, the levels of serum LL-37were significantly high. Conclusion: Our study showed that the low serum levels of vitamin D, and higher blood levels of cathelicidin could form a molecular level clue in the pathogenesis of psoriasis patients, who are more likely to develop co-morbidities.en_US
dc.identifier.citationAl-Mutairi Nawaf, Eassa Bayoumi EL, Nair Vasanthy. Measurement of vitamin D and cathelicidin (LL-37) levels in patients of psoriasis with co-morbidities. Indian Journal of Dermatology, Venereology and Leprology. 2013 Jul-Aug; 79(4): 492-496.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147497
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2013;volume=79;issue=4;spage=492;epage=496;aulast=Al-Mutairien_US
dc.subjectAntimicrobial peptidesen_US
dc.subjectcathelicidin (LL-37)en_US
dc.subjectpsoriasisen_US
dc.subjectserum vitamin Den_US
dc.titleMeasurement of vitamin D and cathelicidin (LL-37) levels in patients of psoriasis with co-morbidities.en_US
dc.typeArticleen_US
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