Noninvasive diagnosis of fetal anemia and fetal intravascular transfusion therapy: experiences at Siriraj Hospital.
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Date
2006-07-03
Authors
Wataganara, Tuangsit
Wiwanichayakul, Booraya
Ruengwuttilert, Pornpimol
Sunsaneevithayakul, Prasert
Viboonchart, Sommai
Wantanasiri, Charnchai
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Abstract
Traditionally, when fetal hydrops are found along with certain markers indicating fetal anemia, fetal blood sampling would be performed through cordocentesis to confirm the diagnosis. This procedure, however comes with an inherent risk of losing the whole pregnancy. When anemia was verified, treatment options were limited and the prognosis was grim. In this article, the authors described their experiences of using prenatal Doppler studies as a noninvasive venue in the diagnosis and treatment of fetal anemia. Once the diagnosis of fetal anemia is made, the patient will be asked to undergo an algorithm to investigate the definite cause of anemia, along with simultaneous ultrasound-guided intravascular fetal transfusion in selected cases. The authors selected two cases of fetal anemia of different etiologies and treatment outcomes to demonstrate the significance of early diagnosis and intervention. Review of the relevant medical literatures and the proposed algorithms were also provided.
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Chotmaihet Thangphaet.
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Citation
Wataganara T, Wiwanichayakul B, Ruengwuttilert P, Sunsaneevithayakul P, Viboonchart S, Wantanasiri C. Noninvasive diagnosis of fetal anemia and fetal intravascular transfusion therapy: experiences at Siriraj Hospital. Journal of the Medical Association of Thailand. 2006 Jul; 89(7): 1036-43