Comparative Study of Efficacy and Safety of Rocuronium Bromide with Suxamethonium Chloride for Tracheal Intubation

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dc.contributor.authorWagh, Aen_US
dc.contributor.authorKarande, Aen_US
dc.contributor.authorPage, Sen_US
dc.contributor.authorDabade, Ven_US
dc.date.accessioned2025-08-13T09:54:22Z
dc.date.available2025-08-13T09:54:22Z
dc.date.issued2025-06
dc.description.abstractBackground: Tracheal intubation is a cornerstone of modern anesthetic practice, with neuromuscular blocking agents playing a critical role. Among these agents, Suxamethonium chloride is widely used for its quick onset and brief duration. However, its associated side effects have prompted the search for alternatives like Rocuronium Bromide, a non-depolarizing agent known for its rapid onset, intermediate duration, and minimal adverse effects. The study aims to compare the effectiveness and safety of Suxamethonium chloride and Rocuronium Bromide. It evaluates their onset times, intubating conditions, duration of action, hemodynamic effects, and adverse reactions. Materials and Methods: A randomized trial was conducted with 110 patients divided into two groups. Group A received Suxamethonium (1.5 mg/kg IV), and Group B was administered Rocuronium (0.9 mg/kg IV). Observations were made on intubation quality, onset timing, and hemodynamic changes. Results: Group A exhibited faster onset and superior intubating conditions (100% excellent scores) compared to Group B (87.3% excellent scores). However, Rocuronium demonstrated longer duration of action, hemodynamic stability, with significantly lower postoperative heart rate and blood pressure fluctuations. Additionally, Group B had no reported adverse effects, while Group A experienced 12.7% postoperative myalgia. Conclusion: Rocuronium represents a safer alternative for tracheal intubation, with enhanced hemodynamic stability and fewer side effects, despite slightly less favorable intubating conditions than Suxamethonium.en_US
dc.identifier.affiliationsDepartment Anaesthesia, Rajiv Gandhi medical college and Chhatrapati Shivajimaharaj hospital (RGMC), Kalwa, Thane, Indiaen_US
dc.identifier.affiliationsDepartment Anaesthesia, Ashwini Rural Medical College, Hospital and Research Centre, Kumbhari, Solapur, Indiaen_US
dc.identifier.affiliationsDepartment Anaesthesia, Ashwini Rural Medical College, Hospital and Research Centre, Kumbhari, Solapur, Indiaen_US
dc.identifier.affiliationsDepartment Anaesthesia, Ashwini Rural Medical College, Hospital and Research Centre, Kumbhari, Solapur, Indiaen_US
dc.identifier.citationWagh A, Karande A, Page S, Dabade V. Comparative Study of Efficacy and Safety of Rocuronium Bromide with Suxamethonium Chloride for Tracheal Intubation. National Journal of Medical Research . 2025 Jun; 15(2): 96-102en_US
dc.identifier.issn2249-4995
dc.identifier.issn2277-8810
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252783
dc.languageenen_US
dc.publisherMedsci Publicationsen_US
dc.relation.issuenumber2en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.55489/njmr.150220251069en_US
dc.subjectRocuronium Bromideen_US
dc.subjectSuxamethonium Chlorideen_US
dc.subjectTracheal Intubationen_US
dc.subjectNeuromuscular Blocking Agentsen_US
dc.subjectHemodynamic Stabilityen_US
dc.subjectPostoperative Myalgiaen_US
dc.titleComparative Study of Efficacy and Safety of Rocuronium Bromide with Suxamethonium Chloride for Tracheal Intubationen_US
dc.typeJournal Articleen_US
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