The protective role of vitamins (C&E), selenium, silymarin and rehydran-N against lead toxicity under heat stress conditions.
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Date
2006-07
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Abstract
This study was done to investigate the use of vitamins C & E, selenium, silymarin and rehydration solution to ameliorate lead toxicity under heat stress conditions. Male albino rats were subdivided into four groups: the first was a control group, the second was exposed to heat stress (40 ± 2°C) in a closed and controlled chamber, the third received 25 mg/100 g body weight lead acetate day by day and exposed to the same heat stress conditions, the fourth was exposed to the same lead and hyperthermia conditions and supplemented three times per week with 1 mg/100 g body weight of each of vitamins C & E, silymarin, and 0.01mg/100g B.W. of selenium, and a daily drink of rehydran-n solution. Blood samples were collected after 25 days of treatment. Lead was found to induce significant elevations in blood glucose, total protein, cholesterol, lead, ALT, AST, GGT, ALP and LDH levels under heat stress conditions. Hyperthermia induced apoptotic DNA fragmentation, which was aggravated under lead intoxication. A reduction in body weight was observed in heat stressed groups. Hepatomegally was observed in heat stressed animals, which was aggravated with lead intake. Under heat stress condition, randomly scattered hepatocytes showed acidophilic and apoptotic changes. Under heat and lead exposure, these changes were enhanced and showed midzonal distribution, in addition to marked periportal microvesicular steatosis. Treatment of rats with vitamins C & E, silymarin, selenium, and rehydran-n resulted in marked improvement in the biochemical, molecular, physiological, and histopathological parameters.
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Rats, Lead, Hyperthermia, Pathology, Apoptosis, Steatosis
Citation
Shalan MG, Abd Ali WDh, El-Batanony MH. The protective role of vitamins (C&E), selenium, silymarin and rehydran-N against lead toxicity under heat stress conditions. Journal of the Indian Society of Toxicology. 2006 Jul; 2(2): 15-22.