Patterns of failure for early-stage glottic carcinoma: 10 years' experience in conformal radiotherapy era

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dc.contributor.authorSert, Fatmaen_US
dc.contributor.authorKaya, Isaen_US
dc.contributor.authorOzturk, Keremen_US
dc.contributor.authorEsassolak, Mustafaen_US
dc.date.accessioned2020-11-18T10:07:40Z
dc.date.available2020-11-18T10:07:40Z
dc.date.issued2019-05
dc.description.abstractPurpose: Larynx cancer is the most common head-and-neck cancer in Turkey. Vocal cords are involved nearly 70%–80% of laryngeal carcinomas. We aim to present our 10 years' experience and failure patterns of the patients with T1 and T2 glottic laryngeal carcinoma by same manner, technique, doses, and physician in conformal radiotherapy (RT) era. Methods: Between January 2005 and December 2015, a total of 143 patients treated with definitive RT for early-stage glottis laryngeal cancer were selected. The total dose was 65.25 Gy in 29 fractions. Results: The median follow-up time was 64 (range: 12–150) months. All of the patients had a complete clinical response to the treatment. A 5-year local control (LC) rates were 84.5%, 91.8%, 74%, and 56% for overall, T1a, T1b, and T2, respectively. Ultimate LC rates (after salvage treatment) for 5 years were 90%, 95%, 92%, and 75% for overall, T1a, T1b, and T2, respectively. Regional neck control for the whole group was 92% for 5 years. After the initial RT, a total of 22 (15.4%) patients had disease recurrence at any site of the neck or larynx. Median time to disease recurrence was 59.5 months (range: 5–150). Conclusion: This study represents a large and long-term analysis of early-stage glottic carcinoma treated by same manner, technique, doses, and physician in conformal RT era. Definitive RT provides a high LC rate, tolerable toxicity, and favorable voice quality. Extension beyond the vocal cords and T2 stage are the most important unfavorable prognostic factors regarding LCen_US
dc.identifier.affiliationsDepartment of Radiation Oncology, Ege University Medical School and Hospital, Izmir, Turkeyen_US
dc.identifier.affiliationsDepartment of Otolaryngology, Ege University Medical School and Hospital, Izmir, Turkeyen_US
dc.identifier.affiliationsDepartment of Otolaryngology, Ege University Medical School and Hospital, Izmir, Turkeyen_US
dc.identifier.affiliationsDepartment of Radiation Oncology, Ege University Medical School and Hospital, Izmir, Turkeyen_US
dc.identifier.citationSert Fatma, Kaya Isa, Ozturk Kerem, Esassolak Mustafa. Patterns of failure for early-stage glottic carcinoma: 10 years' experience in conformal radiotherapy era. Journal of Cancer Research and Therapeutics. 2019 May; 15(3): 576-581en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213661
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_692_17en_US
dc.subjectFailure patternsen_US
dc.subjectglottic laryngeal carcinomaen_US
dc.subjectmiddle‑income countryen_US
dc.subjectradiotherapyen_US
dc.titlePatterns of failure for early-stage glottic carcinoma: 10 years' experience in conformal radiotherapy eraen_US
dc.typeJournal Articleen_US
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