Role of opioid receptors in self-aggression in rats.

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dc.contributor.authorSharma, Ren_US
dc.contributor.authorManchanda, S Ken_US
dc.contributor.authorNayar, Uen_US
dc.date.accessioned1991-07-01en_US
dc.date.accessioned2009-06-01T07:32:31Z
dc.date.available1991-07-01en_US
dc.date.available2009-06-01T07:32:31Z
dc.date.issued1991-07-01en_US
dc.description.abstractSelf-aggression is a behavioural disorder in which an individual damages its own body parts by intense biting or scratching. Self aggression has been reported in human patients in Lesch-Nyhan syndrome and in cases of schizophrenia, depression, and congenital analgesia. In human patients as well as in experimental animals some kind of dysesthesia of the part of the body that is mutilated has been suggested. This study was conducted to find out the underlying pain mechanisms in self-aggressive behaviour arising out of stereotypy. The study was performed in 40 adult male rats. In all these animals, self-aggression was produced as part of amphetamine induced stereotyped behaviour. A predetermined scale was used for quantifying this behaviour. Reserpine and phenoxybenzamine pretreatment led to an increase in the incidence of self-aggression. Naloxone administration in reserpine pretreated animals led to a further significant increase in the incidence of self biting as compared to controls. From these studies it appears that self-aggressive behaviour may be associated with increased pain sensation.en_US
dc.description.affiliationDepartment of Physiology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSharma R, Manchanda SK, Nayar U. Role of opioid receptors in self-aggression in rats. Indian Journal of Physiology and Pharmacology. 1991 Jul; 35(3): 165-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108233
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAggression --drug effectsen_US
dc.subject.meshAmphetamine --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animal --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshNaloxone --pharmacologyen_US
dc.subject.meshNorepinephrine --physiologyen_US
dc.subject.meshPain --physiopathologyen_US
dc.subject.meshPhenoxybenzamine --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Opioid --drug effectsen_US
dc.subject.meshReserpine --pharmacologyen_US
dc.subject.meshSelf Mutilation --physiopathologyen_US
dc.subject.meshTime Factorsen_US
dc.titleRole of opioid receptors in self-aggression in rats.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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