Cross-Allergy of Sulfonamide-Containing Drugs in Sulfonamide Allergic Patients: A Literature Review and Case Study

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dc.contributor.authorFeng, Weileen_US
dc.contributor.authorHuang, Jiawenen_US
dc.contributor.authorTang, Yuwenen_US
dc.contributor.authorZhang, Zhidongen_US
dc.contributor.authorFeng, Xiaofeien_US
dc.contributor.authorZhang, Jianpingen_US
dc.date.accessioned2020-11-18T10:29:11Z
dc.date.available2020-11-18T10:29:11Z
dc.date.issued2020-03
dc.description.abstractThe purpose of this study is to find out whether there are broad cross-reactivity between antibacterial and nonantibacterial sulfonamide agents, the method of the study contained two parts, one is literature research mainlyfrom PubMed database by using the MeSH terms (“Drug name” + allergy); (“Drug name” + hypersensitivity);(“Drug name” + cross-allergenicity) and (“Drug name + cross-reactivity), the search drugs included somecommonly seen medication such as carbonic anhydrase inhibitor, COX-2 inhibitor, loop diuretic, sulfonylurea,thiazide and certain antiviral drugs; the other parts of this thesis is to conduct a statistical review, we screen outpatients who have a previous allergic history of antimicrobial sulfonamides from hospital medical record systemduring Jan 1st, 2015 to Dec 31th, 2016, we did a descriptive statistics of general patients medical information,analyze the suspect cases which patients present potential allergic reaction after using non-antimicrobialsulfonamides agents. Result of literature research reveal there are no convincing evidences and research toconfirm there are bored allergenicity between non-antimicrobial sulfonamides and antimicrobial sulfonamide inthe aspects of chemical structure, immunological study, and large scale population study as well; Result ofhospital patient’s statistics found out there are only 3 suspected cases that the patients were having adverseeffect during their pharmacotherapy from 506 cases. However, we did not found any strong correlation of broadallergenicity between non-antimicrobial sulfonamides and antimicrobial sulfonamides from these suspectedcases. Conclusion: There is minimal evidence of cross-reactivity between the antimicrobial sulfonamides and thenon-antimicrobial sulfonamides. However, the non-antimicrobial sulfonamides are rarely implicated inhypersensitivity reactions as well, so it is impossible to say with certainty that cross-reactivity does not occur.en_US
dc.identifier.affiliationsDepartment of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou 510630, Guangdong, Chinaen_US
dc.identifier.affiliationsCollege of Pharmacy, Jinan University, Guangzhou 510630, Guangdong, Chinaen_US
dc.identifier.citationFeng Weile, Huang Jiawen, Tang Yuwen, Zhang Zhidong, Feng Xiaofei, Zhang Jianping. Cross-Allergy of Sulfonamide-Containing Drugs in Sulfonamide Allergic Patients: A Literature Review and Case Study. Journal of Pharmaceutical and Biomedical Sciences. 2020 Mar; 10(3): 36-51en_US
dc.identifier.issn2230-7885
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215712
dc.languageenen_US
dc.publisherLawarence Press Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume10en_US
dc.source.urihttps://lawarencepress.com/ojs/index.php/JPBMS/article/view/603/pdf_288en_US
dc.subjectSulfonamidesen_US
dc.subjectNon-antimicrobial sulfonamidesen_US
dc.subjectCross-allergenicity.en_US
dc.titleCross-Allergy of Sulfonamide-Containing Drugs in Sulfonamide Allergic Patients: A Literature Review and Case Studyen_US
dc.typeJournal Articleen_US
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