Venifixe: phytovanoactive topical infused oil for healing and preventing epidermal and venous ailments

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dc.contributor.authorApurba, Gen_US
dc.contributor.authorBanerjee, SKen_US
dc.contributor.authorVenkatesh, VSGen_US
dc.contributor.authorSingal, DKen_US
dc.contributor.authorGanguly, A.en_US
dc.date.accessioned2025-05-12T07:25:31Z
dc.date.available2025-05-12T07:25:31Z
dc.date.issued2024-10
dc.description.abstractBackground: This study investigates Venifixe�, a cost-effective phyto-vanoactive infused oil, as an alternative treatment for epidermal and venous ailments (EVA). Venifixe� combines venoactive phyto-complexes, hydrophilic botanical extracts, essential oils, carrier oils, and epidermal care components. The study strives to offer a non-invasive and potentially more effective alternative to conventional treatments, aiming to improve or prevent various EVAs and enhance patients' quality of life. Despite the array of existing treatments, there remains a need for formulations offering enhanced efficacy, reduced invasiveness, and broader applicability. Methods: Over twelve weeks, 250 participants (average age: 59.91�25 years), diagnosed with varicosities via ultrasonography, were included. Participants were divided into two groups: 142 received standard management (SM) for symptomatic EVA, and 108 received Venifixe� treatment. Both groups were assessed for EVA-related symptoms (pain, itchiness, restlessness, swelling/edema, heaviness, and leg cramps) and Venous Clinical Severity Score (VCSS) based on CEAP classification pre-and post-treatment. Results: At twelve weeks, the Venifixe� group demonstrated a VCSS ROC curve (AUC=0.905, 95% CI: 0.89-0.92, p<0.0001), with 93.68% sensitivity, 61.11% specificity, and 75.43% accuracy, indicating favorable treatment outcomes. Significant reductions in VCSS risk ratios and associated symptom prevalence (p<0.0001) led to an improved NHS gradation scale from level 3 to level 2 compared to the SM group. Conclusions: Venifixe�'s topical application provides a more effective phytotherapeutic approach for EVA compared to standard management, offering symptom relief and enhancing quality of life. These results, supported by ROC curves and NHS gradation improvements, warrant further clinical investigation.en_US
dc.identifier.affiliationsNano Phyto Care Pvt. Ltd. 7, Panditya Place, Kolkata- Biochemistry of Techno India University, EM4, Sector V, Salt Lake, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Environmental Science, University of Calcutta. Fellow at West Bengal Academy of Science and Technology, Techno India University, EM4, Sector V, Salt Lake, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Kempegowda Institute of Medical Sciences, RGUHS, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiac Surgery, Board certified in cardiac surgery and a Fellow of the American College of Cardiology (FACC). Somerset, New Jerseyen_US
dc.identifier.affiliationsNano Phyto Care, Pvt Ltd, a premier phytomedicine manufacturing & Marketing Company, Post Graduate in Digital Health, Harvard Medical School from USA, G-1, Pushanjali Farms, Dwarkarla Link Road, Bijwasan, New Delhi, Indiaen_US
dc.identifier.citationApurba G, Banerjee SK, Venkatesh VSG, Singal DK, Ganguly A.. Venifixe: phytovanoactive topical infused oil for healing and preventing epidermal and venous ailments . International Journal of Research in Medical Sciences. 2024 Oct; 12(10): 3721-3730en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246853
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20242932en_US
dc.subjectVenifixe畖|Botanical extractsen_US
dc.subjectChronic venous diseaseen_US
dc.subjectPhyto-venoactive compoundsen_US
dc.subjectSkin healthen_US
dc.subjectTopical therapyen_US
dc.titleVenifixe: phytovanoactive topical infused oil for healing and preventing epidermal and venous ailmentsen_US
dc.typeJournal Articleen_US
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