MESENCHYMAL STEM CELLS: A POSSIBLE SOURCE OF MULTIPLE SCLEROSIS TREATMENT
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Date
2024-07
Journal Title
Journal ISSN
Volume Title
Publisher
Era's Lucknow Medical College & Hospital, Lucknow in association with American University of Barbados (AUB)
Abstract
There are high hopes for stem cell therapies for tissue repair because there are currently no treatments that promote the remyelination and regeneration of the neuronal network that has been damaged by the autoimmune onslaught that is present in multiple sclerosis (MS). Because of their alleged aptitude to transdifferentiate into brain cells and their power to modulate immunological responses, It has been proposed that mesenchymal stem cells (MSCs) could be used to treat MS. In the present review we highlighted the possible use of MSCs in MS patients as an alternate novel option. The small number of MS patients in research and the lack of positive benefits of MSC transplantation in cells treatments have been examined. Furthermore, the primary challenges and hazards associated with MSC therapy for MS patients have been elucidated. In conclusion, the MS treatment with MSC-based stem cell therapy showed lot of promise. However, a multitude of issues and restrictions that need to be fixed. Further research and quantification are required regarding the precise the cell stage to be transplanted, the precise description of the cell type to be given, the transplanted cells' in vivo destiny in different inflammatory models, the dosage, the mode of administration, the length of the therapeutic effect, and the stem cells' genomic stability.
Description
Keywords
Nchymal Stem Cells, Multiple Sclerosis, Homing, Immunomodulation.
Citation
Saharia Violina, Porwal Paras, Gupta Rahul, Ahmad Ausaf . MESENCHYMAL STEM CELLS: A POSSIBLE SOURCE OF MULTIPLE SCLEROSIS TREATMENT. Era's Journal of Medical Research. 2024 Jul; 11(1): 51-55