An update on newer beta-lactamases.

dc.contributor.authorGupta, Varshaen_US
dc.date.accessioned2007-11-28en_US
dc.date.accessioned2009-05-27T07:44:58Z
dc.date.available2007-11-28en_US
dc.date.available2009-05-27T07:44:58Z
dc.date.issued2007-11-28en_US
dc.description142 references.en_US
dc.description.abstractThe resistance to beta-lactam antibiotics is an increasing problem worldwide and beta lactamases production is the most common mechanism of drug resistance. Both global and Indian figures showed a marked increase in the number of beta-lactamases producing organisms. These enzymes extended spectrum beta-lactamases (ESBLs) are numerous and continuous mutation has led to the development of enzymes having expanded substrate profile. To date, there are more than 130 TEM type and more than 50 sulphydryl variable (SHV) type beta-lactamases found in Gram negative bacilli. ESBL producing Enterobacteriaceae are, as a rule, resistant to all cephalosporins and extended spectrum penicillins including the monobactam, aztreonam, while resistance to trimethoprim - sulphamethaxazole and aminoglycosides is frequently co-transferred on the same plasmid. Many ESBL producing organisms also express Amp C beta-lactamases. Amp C- beta-lactamases are clinically significant, as these confer resistance to cephalosporins in the oxyimino group, 7 alpha-methoxy cephalosporins, and are poorly inhibited by clavulanic acid. Carbepenems are the drugs of choice for the treatment of infections caused by ESBL producing organisms but carbapenemases (MBLs) have emerged and have spread from Pseudomonas aeruginosa to Enterobacteriaceae. The routine clinical microbiology laboratories should employ simple methods to recognize these enzymes using various substrates and inhibitors. These organisms may lead to therapeutic dead ends. Presently, the therapy relies on beta-lactam/ beta-lactamases inhibitor combinations, carbepenems and piperacillin - tazobactam plus aminoglycoside combination. Proper infection control practices and barrier precautions are essential to contain the organisms producing beta-lactamases.en_US
dc.description.affiliationDepartment of Microbiology, Government Medical College & Hospital, Chandigarh, India. varshagupta_99@yahoo.comen_US
dc.identifier.citationGupta V. An update on newer beta-lactamases. Indian Journal of Medical Research. 2007 Nov; 126(5): 417-27en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/21920
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshEnterobacteriaceae --drug effectsen_US
dc.subject.meshEnterobacteriaceae Infections --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshbeta-Lactam Resistanceen_US
dc.subject.meshbeta-Lactamases --chemistryen_US
dc.titleAn update on newer beta-lactamases.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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