Stimulation of the absorption of macromolecules in Giardia lamblia infected mice intestine.

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dc.contributor.authorMahmood, Sen_US
dc.contributor.authorGanguly, N Ken_US
dc.contributor.authorMahajan, R Cen_US
dc.contributor.authorWalia, B Nen_US
dc.date.accessioned1990-05-01en_US
dc.date.accessioned2009-05-27T08:47:29Z
dc.date.available1990-05-01en_US
dc.date.available2009-05-27T08:47:29Z
dc.date.issued1990-05-01en_US
dc.description.abstractThe absorption of 125I-labelled bovine serum albumin, gamma-globulin and alpha-lactalbumin was considerably enhanced in G. lamblia infected Swiss mice intestine compared to uninfected controls. The binding of 125I-proteins to brush border membrane was however, significantly (P less than 0.01) low in infected animals. Kinetic studies with gamma-globulin binding to brush borders revealed a decrease in the number of binding sites in infected animals (1.52) compared to controls (2.86 micrograms/mg protein) with no change in the affinity constant (47.60 micrograms/ml) under these conditions. These findings suggest that G. lamblia infection in mice leads to enhanced macromolecular absorption which seems unrelated to the binding of proteins to epithelial cell surface.en_US
dc.description.affiliationDepartment of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh.en_US
dc.identifier.citationMahmood S, Ganguly NK, Mahajan RC, Walia BN. Stimulation of the absorption of macromolecules in Giardia lamblia infected mice intestine. Indian Journal of Medical Research. 1990 May; 91(): 218-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/25648
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshGiardiasis --metabolismen_US
dc.subject.meshIntestinal Absorptionen_US
dc.subject.meshLactalbumin --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMicrovilli --metabolismen_US
dc.subject.meshSerum Albumin, Bovine --metabolismen_US
dc.subject.meshgamma-Globulins --metabolismen_US
dc.titleStimulation of the absorption of macromolecules in Giardia lamblia infected mice intestine.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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