In vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao PDR border areas.

Simple item page
dc.contributor.authorYang, H Len_US
dc.contributor.authorLiu, D Qen_US
dc.contributor.authorYang, Y Men_US
dc.contributor.authorHuang, K Gen_US
dc.contributor.authorDong, Yen_US
dc.contributor.authorYang, P Fen_US
dc.contributor.authorLiao, M Zen_US
dc.contributor.authorZhang, C Yen_US
dc.date.accessioned2009-05-27T15:08:56Z
dc.date.available2009-05-27T15:08:56Z
dc.date.issued1997-09-30en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractIn 1991-1995 by using the Rieckmann in vitro micro-method, susceptibilities of Plasmodium falciparum to eight antimalarials in the China-Lao PDR and China-Myanmar border areas were tested. The resistant rates of P. falciparum to chloroquinine were 95.0%-100%; IC50 114-240nmol/l. P. falciparum resistant rates to amodiaquine resistance accounted for 83.5%-100%, IC50 52-72nmol/l. All cases were sensitive to quinine, IC50 470-608nmol/l. P. falciparum isolates from the Lao PDR frontier were highly sensitive to artesunate, dihydroartemisinin, and arteether. Resistant rates from other areas were 0-11%. P. falciparum from China-Myanmar and Lao PDR border areas were also sensitive to mefloquine, IC50 68-88nmol/l. A longitudinal survey of the sensitivity of P. falciparum in vivo on the China-Lao PDR border showed that the average defervescent time of falciparum malaria was treated by pyronaridine increased from 32.7 +/- 16.0 hours during 1984-85 to 56.2 +/- 27.4 hours in 1995; the recrudescence rate rose up from 15.2% to 37.5%. The results monitored in vitro showed that all cases assessed in 1988 for response to pyronaridine were sensitive, but 36.4% of cases had emerging resistance, IC50 increased from 13nmol/l to 40 nmol/l. The above results suggested that P. falciparum in these areas has expressed resistance to chloroquine and amodiaquine. However, the parasites are still sensitive to artemisinin, pyronaridine, mefloquine, quinine, but with a declining sensitivities.en_US
dc.description.affiliationYunnan Institute of Malaria Control, Simao, People's Republic of China.en_US
dc.identifier.citationYang HL, Liu DQ, Yang YM, Huang KG, Dong Y, Yang PF, Liao MZ, Zhang CY. In vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao PDR border areas. The Southeast Asian Journal of Tropical Medicine and Public Health. 1997 Sep; 28(3): 460-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32039
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAmodiaquine --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimalarials --pharmacologyen_US
dc.subject.meshArtemisininsen_US
dc.subject.meshChinaen_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshHumansen_US
dc.subject.meshLaosen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshMyanmaren_US
dc.subject.meshNaphthyridines --pharmacologyen_US
dc.subject.meshPlasmodium falciparum --drug effectsen_US
dc.subject.meshQuinine --pharmacologyen_US
dc.subject.meshSesquiterpenes --pharmacologyen_US
dc.titleIn vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao PDR border areas.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Southeast Asian Journal of Tropical Medicine and Public Health