Effect of corticosteroid treatment on various serological & bronchoalveolar lavage abnormalities in patients with sarcoidosis.

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dc.contributor.authorSharma, S Ken_US
dc.contributor.authorKhanna, Men_US
dc.contributor.authorSharma, Sen_US
dc.contributor.authorSrivastava, L Men_US
dc.contributor.authorVerma, Ken_US
dc.contributor.authorKhilnani, G Cen_US
dc.contributor.authorPande, J Nen_US
dc.date.accessioned1995-05-01en_US
dc.date.accessioned2009-05-27T07:43:39Z
dc.date.available1995-05-01en_US
dc.date.available2009-05-27T07:43:39Z
dc.date.issued1995-05-01en_US
dc.description.abstractEffect of daily oral prednisolone treatment was studied in 29 patients with pulmonary sarcoidosis. Twenty normal control subjects were also studied. Pretreatment absolute lymphocyte counts and proportion of lymphocytes in peripheral blood were significantly lower in patients with sarcoidosis as compared to normal controls. Total cell count and the proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid were significantly higher in sarcoidosis. The proportion of CD3+ and CD4+ was significantly lower in peripheral blood and higher in BAL fluid in patients with sarcoidosis. Immunoglobulins (IgG, A and M) and complements (C3, C4 and CH50) were significantly higher both in peripheral blood and BAL fluid. Patients with sarcoidosis were treated with daily oral prednisolone (30 mg/day). Repeat studies were performed after an interval of 4-6 months in 20 patients with sarcoidosis. A significant increase in absolute lymphocyte counts in peripheral blood and decrease in the proportion of lymphocytes in BAL fluid occurred with prednisolone treatment. Proportion of CD3+, CD4+ and B cells increased in peripheral blood and decreased in BAL fluid. Complement and immunoglobulin levels revealed a significant reduction in peripheral blood and BAL fluid. It is concluded that patients with sarcoidosis have peripheral blood lymphopaenia and lymphocytic alveolitis. They have increased levels of complement and immunoglobulins both in the peripheral blood and BAL fluid. All these abnormalities show significant improvement with prednisolone treatment.en_US
dc.description.affiliationDepartment of Medicine, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSharma SK, Khanna M, Sharma S, Srivastava LM, Verma K, Khilnani GC, Pande JN. Effect of corticosteroid treatment on various serological & bronchoalveolar lavage abnormalities in patients with sarcoidosis. Indian Journal of Medical Research. 1995 May; 101(): 207-12en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/21833
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshBronchoalveolar Lavage Fluid --cytologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrednisolone --therapeutic useen_US
dc.subject.meshSarcoidosis, Pulmonary --drug therapyen_US
dc.subject.meshSerologic Testsen_US
dc.titleEffect of corticosteroid treatment on various serological & bronchoalveolar lavage abnormalities in patients with sarcoidosis.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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