The feasibility of a school-based VI polysaccharide vaccine mass immunization campaign in Hue City, central Vietnam: streamlining a typhoid fever preventive strategy.

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dc.contributor.authorThiem, Vu Dinhen_US
dc.contributor.authorDanovaro-Holliday, M Carolinaen_US
dc.contributor.authorCanh, Do Giaen_US
dc.contributor.authorSon, Nguyen Dinhen_US
dc.contributor.authorHoa, Nyugen Thaien_US
dc.contributor.authorThuy, Dang Thi Dieuen_US
dc.contributor.authorOchiai, R Leonen_US
dc.contributor.authorLan, Nguyen Thien_US
dc.contributor.authorHop, Tran Quangen_US
dc.contributor.authorAli, Mohammaden_US
dc.contributor.authorPark, Jin Kyungen_US
dc.contributor.authorAbu-Elyazeed, Remonen_US
dc.contributor.authorHolliday, Krisen_US
dc.contributor.authorIvanoff, Bernarden_US
dc.contributor.authorAnh, Dang Ducen_US
dc.contributor.authorPang, Tikkien_US
dc.contributor.authorDonner, Allanen_US
dc.contributor.authorGalindo, Claudia Men_US
dc.contributor.authorTrach, Dang Ducen_US
dc.contributor.authorClemens, John Den_US
dc.contributor.authorAcosta, Camilo Jen_US
dc.date.accessioned2009-05-27T14:36:23Z
dc.date.available2009-05-27T14:36:23Z
dc.date.issued2006-05-24en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractWe report the coverage, safety, and logistics of a school-based typhoid fever immunization campaign that took place in Hue City, central Vietnam; a typhoid fever endemic area. A cluster-randomized evaluation-blinded controlled trial was designed where 68 schools (cluster) were randomly allocated the single dose Vi polysaccharide vaccine (Typherix) or the active control hepatitis A vaccine (Havrix). A safety surveillance system was implemented. A total of 32,267 children were immunized with a coverage of 57.5%. Strong predictors for vaccination were attending primary schools, peri-urban location of the school, and low family income. Human resources were mainly schoolteachers and the campaign was completed in about 1 month. Most adverse events reported were mild. Safe injection and safe sharp-waste disposal practices were followed. A typhoid fever school-based immunization campaign was safe and logistically possible. Coverage was moderate and can be interpreted as the minimum that could have been achievable because individual written informed consent procedures were sought for the first time in Hue City and the trial nature of the campaign. The lessons learned, together with cost-effectiveness results to be obtained by the end of follow-up period, will hopefully accelerate the introduction of Vi typhoid fever vaccine in Vietnam.en_US
dc.description.affiliationNational Institute of Hygiene and Epidemiology, Hanoi, People's Republic of Vietnam.en_US
dc.identifier.citationThiem VD, Danovaro-Holliday MC, Canh do G, Son ND, Hoa NT, Thuy DT, Ochiai RL, Lan NT, Hop TQ, Ali M, Park JK, Abu-Elyazeed R, Holliday K, Ivanoff B, Anh DD, Pang T, Donner A, Galindo CM, Trach DD, Clemens JD, Acosta CJ. The feasibility of a school-based VI polysaccharide vaccine mass immunization campaign in Hue City, central Vietnam: streamlining a typhoid fever preventive strategy. The Southeast Asian Journal of Tropical Medicine and Public Health. 2006 May; 37(3): 515-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30584
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2006_37_3/13-3743.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshFeasibility Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunization Programs --organization & administrationen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Immunizationen_US
dc.subject.meshPolysaccharides, Bacterial --adverse effectsen_US
dc.subject.meshSchool Health Services --organization & administrationen_US
dc.subject.meshSingle-Blind Methoden_US
dc.subject.meshTyphoid Fever --prevention & controlen_US
dc.subject.meshTyphoid-Paratyphoid Vaccines --adverse effectsen_US
dc.subject.meshVietnamen_US
dc.titleThe feasibility of a school-based VI polysaccharide vaccine mass immunization campaign in Hue City, central Vietnam: streamlining a typhoid fever preventive strategy.en_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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