HBV specific T-cell responses in hepatitis B.
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Date
2011-10
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Abstract
Background: Cellular immune responses seem to prevail in acute hepatitis, whereas chronically
infected patients demonstrate generally suppressed cellular immune responses and
significantly greater antibody responses.
Aim: To study hepatitis B virus (HBV) specific T cell proliferative responses in HBV related
liver diseases.
Methods: We analyzed the T lymphocyte proliferative responses to the nonspecific mitogen
phytohemagglutinin (PHA) and the HBV specific hepatitis B core antigen (HBcAg) by
calculating T cell proliferation index in 10 acute viral hepatitis (AVH) patients, 19 chronic
hepatitis B (CHB) patients, 10 HBV cirrhotics, 10 inactive carriers and 10 healthy controls
using MTT assay.
Results: The mean proliferation index (PI) to PHA was highest in healthy controls (133.2 +
58.1) and lowest in cirrhotics (44.1 + 46.9) with all other groups falling in between. On comparing
the mean T cell responses to HBcAg, AVH patients had the highest mean response (186.48 +
116.37) followed by CHB (137.9 + 134.3), inactive carriers (63.2 + 41.2) and cirrhotics (55.5 +
42.7).
Conclusions: Patients with AVH had the highest T cell response to HBcAg, which probably explains the clearance of virus in these patients, in contrast to patients with cirrhosis who had the lowest T cell response.
Description
Keywords
Hepatitis B virus, immune response, proliferation index
Citation
Rana Deepa, Menachery John, Chawla Yogesh, Duseja Ajay, Dhiman Radha, Arora Sunil. HBV specific T-cell responses in hepatitis B. Tropical Gastroenterology. 2011 Oct-Dec; 32(4): 273-278.